Neurotoxic effects of Cis-bifenthrin on microbe-gut-brain axis: Disruption of neurolipid balance in Xenopus laevis
文献类型： 外文期刊
作者： Li, Meng 1 ; Li, Chenxi 1 ; He, Mengai 1 ; Chen, Liezhong 1 ; Wang, Qiangwei 2 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Qual & Safety Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
2.Zhejiang Univ, Inst Pesticide & Environm Toxicol,Minist Agr, Key Lab Mol Biol Crop Pathogens & Insects, Zhejiang Key Lab Biol & Ecol Regulat Crop Pathogen, Hangzhou 310058, Peoples R China
关键词： Cis -bifenthrin; Xenopus laevis; Neurolipid disorder; Microbe-gut-brain axis; Neurodegenerative diseases
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）
ISSN： 0147-6513
年卷期： 2025 年 302 卷
页码：
收录情况： SCI
摘要： The neurotoxic effects of cis-bifenthrin (cis-BF) on amphibians and its molecular mechanisms are unclear despite its common presence in aquatic environments. In present study, female Xenopus laevis were subjected to a threemonth treatment with environmentally relevant concentrations of 60 and 300 ng/L cis-BF. Metabolomic analysis of brain tissue revealed differential metabolites enriching bile acid (BA) synthesis, impacting beta-amyloid protein deposition. Reduced polyunsaturated fatty acids (PUFAs), essential for membrane integrity, were observed. Elevated amyloid beta-protein and lipopolysaccharide (LPS) levels suggested potential Alzheimer's-like symptoms induced by cis-BF. Given PUFAs and BAs are processed via enterohepatic circulation, a notable decrease in the abundance of genera linked to PUFAs and BAs metabolism was observed. Gut metabolomics revealed decreased concentrations of PUFAs and secondary BAs across cis-BF treatment groups, attributed to changes in associated microbial communities. Cis-BF exposure raised intestinal LPS levels and plasma proinflammatory cytokines, resulting in intestinal damage. This facilitated the entry of LPS into the bloodstream and brain tissue, indicating a cytokine-LPS interaction that promotes LPS transit to the brain through the bloodstream. Our study suggests that cis-BF-induced alterations in gut microbiota and metabolism may trigger Alzheimer's-related neurological disorders in Xenopus laevis via the gut-brain axis by inducing neurolipid disorder and inflammation.
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