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Effect of mussel polysaccharide on glucolipid metabolism and intestinal flora in type 2 diabetic mice

文献类型： 外文期刊

作者： Wang, Rui 1 ; Yang, Xingwen 1 ; Jiang, Qihong 1 ; Chen, Lin 5 ; Gu, Saiqi 1 ; Shen, Guoxin 5 ; Liu, Shulai 1 ; Xiang, Xingwei 1 ;

作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China

2.Key Lab Marine Fishery Resources Exploitment & Uti, Hangzhou, Peoples R China

3.Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzhou, Hangzhou, Peoples R China

4.Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian, Peoples R China

5.Zhejiang Acad Agr Sci, Hangzhou, Peoples R China

关键词： type 2 diabetes mellitus; mussel polysaccharide; insulin resistance; intestinal flora

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.1； 五年影响因子：4.2 ）

ISSN： 0022-5142

年卷期： 2023 年 103 卷 7 期

页码：

收录情况： SCI

摘要： BACKGROUNDType 2 diabetes (T2D) mellitus is a major metabolic disease, and its incidence and lethality have increased significantly in recent years, making it a serious threat to human health. Among numerous previous studies, polysaccharides have been shown to alleviate the adverse effects of T2D, but there are still problems such as insufficient analysis and poor understanding of the mechanisms by which polysaccharides, especially those of marine origin, regulate T2D. METHODSIn this study, we used multiple allosteric approaches to further investigate the regulatory effects of mussel polysaccharides (MPs) on T2D and gut microbiota disorders in mice by identifying changes in genes, proteins, metabolites and target organs associated with glucolipid metabolism using an animal model of T2D fed with high-fat diets, and to explore the underlying molecular mechanisms. RESULTSAfter MP intervention, serum levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and high-density lipoprotein cholesterol (HDL-C) were up-regulated, and blood glucose and lipid levels were effectively reduced in T2D mice. Activation of signaling molecules related to the upstream and downstream of the insulin PI3K/Akt signaling pathway reduced hepatic insulin resistance. The relative abundance of short-chain fatty acid (SCFA)-producing bacteria (including Akkermansia, Siraeum Eubacterium and Allobaculum) increased and harmful desulfurizing Vibrio decreased. In addition, the levels of SCFAs were increased. CONCLUSIONThese results suggest that MP can increase SCFA levels by altering the abundance of intestinal flora, thereby activating the PI3K/Akt signaling pathway and exerting hypoglycemic effects. (c) 2023 Society of Chemical Industry.

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