Approaches for Modes of Action Study of Long Non-Coding RNAs: From Single Verification to Genome-Wide Determination
文献类型： 外文期刊
作者： Tao, Xiaoyuan 1 ; Li, Sujuan 2 ; Chen, Guang 2 ; Wang, Jian 2 ; Xu, Shengchun 1 ;
作者机构： 1.Xianghu Lab, Hangzhou 311231, Peoples R China
2.Zhejiang Acad Agr Sci, Cent Lab, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
关键词： lncRNA; epigenetics; RNA-DNA interaction; RNA-protein interaction; ribonucleoprotein; chromatin accessibility
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）
ISSN：
年卷期： 2023 年 24 卷 6 期
页码：
收录情况： SCI
摘要： Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nt) that are not translated into known functional proteins. This broad definition covers a large collection of transcripts with diverse genomic origins, biogenesis, and modes of action. Thus, it is very important to choose appropriate research methodologies when investigating lncRNAs with biological significance. Multiple reviews to date have summarized the mechanisms of lncRNA biogenesis, their localization, their functions in gene regulation at multiple levels, and also their potential applications. However, little has been reviewed on the leading strategies for lncRNA research. Here, we generalize a basic and systemic mind map for lncRNA research and discuss the mechanisms and the application scenarios of 'up-to-date' techniques as applied to molecular function studies of lncRNAs. Taking advantage of documented lncRNA research paradigms as examples, we aim to provide an overview of the developing techniques for elucidating lncRNA interactions with genomic DNA, proteins, and other RNAs. In the end, we propose the future direction and potential technological challenges of lncRNA studies, focusing on techniques and applications.
- 相关文献
作者其他论文 更多>>
-
Differential selection of yield and quality traits has shaped genomic signatures of cowpea domestication and improvement
作者：Wu, Xinyi;Li, Mao;Dong, Junyang;Wang, Baogen;Wu, Jian;Wu, Xiaohua;Wang, Ying;Wang, Jian;Lu, Zhongfu;Sun, Yuyan;Dong, Wenqi;Li, Guojing;Hu, Zhongyuan;Liao, Nanqiao;Zhang, Mingfang;Zhang, Yan;Yang, Yi;Li, Mao;Dong, Junyang;Wang, Baogen;Wu, Jian;Wu, Xiaohua;Wang, Ying;Wang, Jian;Lu, Zhongfu;Sun, Yuyan;Dong, Wenqi;Li, Guojing;Zhang, Mingfang;Zhang, Mingfang
关键词：
-
Cr(VI) behaves differently than Cr(III) in the uptake, translocation and detoxification in rice roots
作者：Riaz, Adeel;Qin, Yuan;Zheng, Qingfeng;Chen, Xuan;Jiang, Wei;Riaz, Bisma;Xiao, Nayun;Wu, Xiaojian;Qiu, Xianjin;Deng, Fenglin;Zeng, Fanrong;Riaz, Adeel;Qin, Yuan;Zheng, Qingfeng;Chen, Xuan;Jiang, Wei;Riaz, Bisma;Xiao, Nayun;Wu, Xiaojian;Qiu, Xianjin;Deng, Fenglin;Zeng, Fanrong;Xu, Jianlong;Xu, Jianlong;Chen, Guang;Chen, Zhong-Hua;Chen, Zhong-Hua
关键词：Chromium; Intracellular transport; ROS homeostasis; ABC transporters; Glutathione S-transferases
-
Molecular and physiological evidence of HvCaLB1 regulates calcium homeostasis and salt tolerance in Barley
作者：Tong, Tao;Zhang, Yanli;Jiang, Wei;Zeng, Fanrong;Qin, Yuan;Deng, Fenglin;Zhou, Xueyi;Chen, Guang;Xue, Dawei;Chen, Zhong-Hua;Chen, Zhong-Hua
关键词：Ca2+-binding domains; Evolutionary bioinformatics; Salinity; Ion homeostasis; Hordeum vulgare L. Ca2+-dependent lipid-binding
-
Stomatal evolution and plant adaptation to future climate
作者：Chen, Guang;Wang, Jian;Li, Sujuan;Xu, Shengchun;Qin, Yuan;Zeng, Fanrong;Deng, Fenglin;Chater, Caspar;Chater, Caspar;Xu, Shengchun;Chen, Zhong-Hua;Chen, Zhong-Hua
关键词：abiotic stresses; climate change; membrane transporters; molecular evolution; photosynthesis; stomatal guard cell; sustainable plant production
-
T2T reference genome assembly and genome-wide association study reveal the genetic basis of Chinese bayberry fruit quality
作者：Zhang, Shuwen;Yu, Zheping;Sun, Li;Liang, Senmiao;Xu, Fei;Li, Sujuan;Zheng, Xiliang;Qi, Xingjiang;Ren, Haiying;Yan, Lijv;Huang, Yinghong;Qi, Xingjiang
关键词：
-
Effect of two different Flammulina velutipes polysaccharides on the physicochemical and digestive properties of rice starch and their interaction mechanisms
作者：Bu, Tingting;Ren, Yuting;Yu, Yue;Lu, Jun;Wang, Jian;Cai, Ming;Yang, Kai;Sun, Peilong;Bu, Tingting;Ren, Yuting;Yu, Yue;Wang, Jian;Cai, Ming;Yang, Kai;Sun, Peilong;Wu, Weicheng;Zhang, Zhiguo;Hu, Weiwei;Lu, Jun
关键词：Flammulina velutipes; Polysaccharides; Rice starch; Pasting; Gelatinization; Starch digestion
-
Effects of PLA/PBAT-based biodegradable film mulch on water and nitrogen dynamics in soil-potato system
作者：Yang, Chong;Feng, Shouli;Yu, Jingyin;Tao, Xiaoyuan;Xu, Shengchun;Gao, Xuhua;Xu, Shengchun
关键词：Biodegradable film mulch; Bio-based materials; Soil nitrogen; Nitrate accumulation; Plant nitrogen uptake
