Polysaccharides of Floccularia luteovirens Alleviate Oxidative Damage and Inflammatory Parameters of Diabetic Nephropathy in db/db Mice
文献类型： 外文期刊
作者： Wang, Huan 1 ; Yang, Yang 1 ; Wang, Shumin 2 ; Li, Changtian 1 ; Chen, Changbao 2 ; Wan, Xilin 2 ; Li, Dan 1 ; Li, Yu 1 ;
作者机构： 1.Jilin Agr Univ, Natl Local Joint Engn Res Ctr Econ Fungus, Changchun 130118, Jilin, Peoples R China
2.Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Jilin, Peoples R China
3.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Haikou 571101, Hainan, Peoples R China
关键词： Floccularia luteovirens; diabetic nephropathy; fungal polysaccharide; oxidative stress; inflammation
期刊名称：FRONTIERS IN BIOSCIENCE-LANDMARK （ 影响因子：3.1； 五年影响因子：3.9 ）
ISSN： 2768-6701
年卷期： 2023 年 28 卷 4 期
页码：
收录情况： SCI
摘要： Background: Floccularia luteovirens (Alb. & Schwein.) Pouzar, is an extremely rare edible and medicinal mushroom in China. The crude polysaccharides of F. luteovirens (FLPs) has significant antioxidant and anti-inflammation activities and exerts excellent protective functions in diabetic nephropathy (DN) complications, but the material basis of the pharmacological effects of FLPs and the molecular mechanism of its pharmacological action are still unclear. Methods: First, we performed systemic composition analysis on extracted and isolated FLPs. Next, the spontaneous db/db mouse DN model was used to investigate the mitigation and protection functions of FLPs in DN and the underlying mechanism through the mammalian target of the rapamycin (mTOR)/GSK-3 beta/NRF-2 pathway. Results: FLPs contained 65.0% total sugars, 7.2% reducing sugars, 7.93% proteins, 0.36% total flavonoids, 17 amino acids, 13 fatty acids, and 8 minerals. After intragastric administration of FLPs with concentrations of 100, 200 and 400 mg/kg for 8 weeks, FLPs inhibited excessive weight gain, relieved the symptoms of obesity, and significantly improved glucose metabolism and lipid metabolism in the db/db mice. In addition, FLPs were also involved in regulating the indicators of various oxidases and inflammatory factors in the serum and kidney of db/db mice. Conclusions: FLPs effectively improved and relieved kidney tissue injury caused by high glucose, targeted and regulated phospho-GSK-3 beta, and suppressed inflammatory factor accumulation. Furthermore, FLPs activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (NRF2/HO-1) pathway and enhanced the activity of catalase (CAT) to further play a role in relieving and treating T2DM and nephropathy complications.
- 相关文献
作者其他论文 更多>>
-
Adulteration identification of Hainan camellia (Camellia oleifera Abel.) oil based on comprehensive two-dimensional gas chromatography and quadrupole time-of-flight mass coupled with chemometrics spectrometry
作者：Zheng, Xiaoyan;Ai, Binling;Yang, Yang;Zheng, Lili;Xiao, Dao;Zhang, Shanying;Zhu, Kexue;Sheng, Zhanwu
关键词：Adulteration; GC x GC-Q-TOFMS; Hainan camellia oil; marker
-
Lysozyme amyloid fibril-chitosan double network hydrogel: Preparation, characterization, and application on inhibition of Nε-(carboxyethyl)lysine
作者：Tian, Ziang;Ai, Binling;Yang, Yang;Zheng, Xiaoyan;Xiao, Dao;Zheng, Lili;Sheng, Zhanwu;Tian, Ziang;Zhang, Zhengke;Wang, Mingfu
关键词：Double network hydrogel; Chitosan; Amyloid fibrils; Gallic acid; N epsilon -(carboxyethyl)lysine
-
Modulatory effects of tryptophan on advanced glycation end products formation and flavor enhancement in high-protein intermediate-moisture food during storage
作者：Zheng, Xiaoyan;Ai, Binling;Zheng, Lili;Liu, Weiyan;Yang, Yang;Xiao, Dao;Sheng, Zhanwu
关键词：Tryptophan; Advanced glycation end products; Intermediate-moisture food; Volatile organic compound
-
Dielectric barrier discharge cold plasma modifies the multiscale structure and functional properties of banana starch
作者：Yang, Yang;Zheng, Xiaoyan;Xiao, Dao;Ai, Binling;Sheng, Zhanwu;Yang, Yang;Zheng, Xiaoyan;Xiao, Dao;Ai, Binling
关键词：Banana starch; Resistant starch; Dielectric barrier discharge; Rheological properties; Digestibility
-
Volatile aroma compounds of passion fruit seed Oils: HS-GC-IMS analysis and interpretation
作者：Zheng, Lili;Wang, Shenwan;Yang, Yang;Zheng, Xiaoyan;Xiao, Dao;Ai, Binling;Sheng, Zhanwu;Wang, Shenwan
关键词：Passion fruit seed oil; Cold -pressed; Volatile compounds; HS-GC-IMS; Aroma
-
Critical Secondary Metabolites Confer the Broad-Spectrum Pathogenic Fungi Resistance Property of a Marine-Originating Streptomyces sp. HNBCa1
作者：Xiong, Zijun;Wu, Weicheng;Qi, Min;Zhang, Shiqing;Guo, Zhikai;Xia, Tengfei;Zheng, Daojun;Wu, Weicheng;Qi, Min;Li, Jitao;Wang, Rong;Yang, Yang;Lin, Shuangjun
关键词：broad-spectrum resistance; secondary metabolites; pathogenic fungi; antifungal activity; biocontrol
-
Environmental damages, cumulative exergy demand, and economic assessment of Panus giganteus farming with the application of solar technology
作者：Cheng, Hanting;Zhou, Xiaohui;Yang, Yang;Xu, Lin;Ding, Ye;Yan, Tinglian;Li, Qinfen;Cheng, Hanting;Zhou, Xiaohui;Yang, Yang;Li, Qinfen;Xu, Lin;Ding, Ye;Li, Qinfen;Yan, Tinglian;Li, Qinfen
关键词：Life-cycle assessment; Cumulative exergy demand; Economic analysis; Mushroom; Photovoltaic
