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Metabolomic profiling and antidiabetic activity of Callerya speciosa

文献类型： 外文期刊

作者： Yang, Qing 1 ; Wang, Qinglong 1 ; Wang, Zhunian 1 ; Li, Zhiying 1 ; Tang, Huan 1 ; Yan, Xiaoxia 1 ; Feng, Shixiu 3 ; Wang, Maoyuan 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Minist Agr, Minist Agr & Rural Affairs,Trop Wild Plant Gene Re, Key Lab Biol & Cultivat Herb Med Haikou,Trop Crops, Haikou, Peoples R China

2.Hainan Prov Engn Res Ctr Trop Med Plants, Haikou, Peoples R China

3.Fairy Lake Bot Garden, Key Lab South Subtrop Plant Divers, Shenzhen, Peoples R China

4.Chinese Acad Sci, Shenzhen, Peoples R China

关键词： Callerya speciosa; UPLC-Q-TOF-MS/MS; metabolomic profiling; anti-diabetic activity; bioavailability

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）

ISSN： 1478-6419

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Callerya speciosa is a perennial edible and medicinal plant belonging to the family Fabaceae. This study was to reveal the similarities and differences between phytochemicals in different parts of C. speciosa using a combination of ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), principal component analysis (PCA) and orthogonal projection to latent structures discriminant analysis (OPLS-DA). In addition, the anti-diabetic activity of C. speciosa extracts was explored. A total of 141 compounds were identified and 34 robustly known chemical markers were marked. PCA and heat map analyses revealed that the stems, leaves and pods had similar phytochemical compounds, while compounds in roots and flowers differed from each other and from those in the above ground parts. In addition, extracts of C. speciosa roots and flowers exhibited anti-diabetic activity, which can be applied to the development of anti-diabetic drugs.

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