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Structural Characterization and Hypoglycemic Activity of a Novel Pumpkin Peel Polysaccharide-Chromium(III) Complex

文献类型： 外文期刊

作者： Zhang, Wen 1 ; Li, Lingyu 1 ; Ma, Yue 2 ; Chen, Xiaole 1 ; Lan, Tao 3 ; Chen, Long 4 ; Zheng, Zhenjia 1 ;

作者机构： 1.Shandong Agr Univ, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control Shandong, 61 Daizong St, Tai An 271018, Shandong, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing Key Lab Agr Prod Fruits & Vegetables Pres, Key Lab Vegetable Postharvest Proc,Minist Agr & R, Beijing 100097, Peoples R China

3.China Natl Inst Standardizat, Sub Inst Agr & Food Standardizat, Beijing 100191, Peoples R China

4.Qilu Univ Technol, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Shandong Acad Sci, Jinan 250014, Peoples R China

关键词： pumpkin peel polysaccharide; chromium (III); structure; hypoglycemic activity

期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）

ISSN：

年卷期： 2022 年 11 卷 13 期

页码：

收录情况： SCI

摘要： The aim of our study was to synthesize a pumpkin peel polysaccharide (PPP)-Cr(III) complex and investigate its hypoglycemic activity. Firstly, a novel PPP-Cr(III) complex with a Cr content of 23.77 mg/g was synthesized and characterized. Physicochemical characterization indicated that PPP-Cr(III) had some changes in chemical composition, monosaccharide composition, and morphological structure compared with PPP. The molecular weights of PPP-Cr(III) and PPP were 1.398 x 10(6) g/mol and 3.386 x 10(6) g/mol, respectively, showing a lower molecular weight after the introduction of Cr(III). Fourier transform infrared spectroscopy showed that a new characteristic absorption peak of Cr-O appeared at 534 cm(-1) in PPP-Cr(III), indicating that Cr(III) was successfully complexed with PPP. Secondly, the hypoglycemic activity of PPP-Cr(III) based on alpha-glucosidase inhibitory and insulin resistance (IR)-HepG2 cells was evaluated. Compared with PPP, PPP-Cr(III) exhibited a more significantly alpha-glucosidase inhibitory activity. The IR-HepG2 cells confirmed an obvious increase in glucose consumption. Western blot analysis demonstrated that the treated IR-HepG2 cells were able to increase the protein levels of p-AMPK and p-GSK-3 beta, indicating that IR-HepG2 cells exerted hypoglycemic activity via the AMPK/GSK-3 beta signaling pathway. These results suggested that PPP-Cr(III) had good hypoglycemic activity, which could provide theoretical support for the development of novel hypoglycemic products.

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