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Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy

文献类型： 外文期刊

作者： Xue, Xiangdong 1 ; Huang, Yee 1 ; Wang, Xinshuai 1 ; Wang, Zhongling 1 ; Carney, Randy P. 1 ; Li, Xiaocen 1 ; Yuan, Ye 1 ;

作者机构： 1.Univ Calif Davis, UC Davis Comprehens Canc Ctr, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

2.Univ Calif Davis, Dept Internal Med, Div Hematol Oncol, Sacramento, CA 95817 USA

3.Zhejiang Acad Agr Sci, Inst Aminal Husb & Vet Sci, Hangzhou

关键词： Drug delivery; Nanoparticles; Self-indication; Multi-modal therapy; Cancer therapy

期刊名称：BIOMATERIALS （ 影响因子：12.479； 五年影响因子：12.104 ）

ISSN： 0142-9612

年卷期： 2018 年 161 卷

页码：

收录情况： SCI

摘要： Conventional drug delivery systems contain substantial amounts of excipients such as polymers and lipids, typically with low drug loading capacity and lack of intrinsic traceability and multifunctionality. Here, we report fully active pharmaceutical ingredient nanoparticles (FAPIN) which were self-assembled by minimal materials, but seamlessly orchestrated versatile theranostic functionalities including: i) self delivery: no additional carriers were required, all components in the formulation are active pharmaceutical ingredients; ii) self-indicating: no additional imaging tags were needed. The nanoparticle itself was composed of 100% imaging agents, so that the stability, drug release, subcellular dispositions, biodistribution and therapeutic efficacy of FAPINs can be readily visualized by ample imaging capacities, including energy transfer relay dominated, dual-color fluorogenic property, near-infrared fluorescence imaging and magnetic resonance imaging; and iii) highly effective trimodality cancer therapy, encompassing photodynamic-, photothermal- and chemo-therapies. FAPIN5 were fabricated with very simple material (a photosensitizer-drug conjugate), unusually achieved similar to 10 times better in vitro antitumor activity than their free counterparts, and were remarkably efficacious in patient-derived xenograft (PDX) glioblastoma multiforme animal models. Only two doses of FAPIN5 enabled complete ablation of highly malignant PDX tumors in 50% of the mice. (C) 2018 Elsevier Ltd. All rights reserved.

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