Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
文献类型： 外文期刊
作者： Long, Qilai 1 ; Lin, Tzu-yin 2 ; Huang, Yee 3 ; Li, Xiaocen 3 ; Ma, Ai-hong 2 ; Zhang, Hongyong 2 ; Carney, Randy 3 ; Air 1 ;
作者机构： 1.Fudan Univ, Zhongshan Hosp, Dept Urol, Shanghai, Peoples R China
2.Univ Calif Davis, Dept Internal Med, Sacramento, CA 95817 USA
3.Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
4.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou, Zhejiang, Peoples R China
5.Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
6.Univ Calif Davis, Dept Urol, Sacramento, CA 95817 USA
7.VA Northern Calif Hlth Care Syst, Mather, CA USA
关键词： Photodynamic therapy; Photothermal therapy; HSP90 inhibitor; Bladder cancer; Nanoparticle
期刊名称：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE （ 影响因子：6.458； 五年影响因子：7.072 ）
ISSN： 1549-9634
年卷期： 2018 年 14 卷 3 期
页码：
收录情况： SCI
摘要： Photodynamic therapy is a promising and effective non-invasive therapeutic approach for the treatment of bladder cancers. Therapies targeting HSP90 have the advantage of tumor cell selectivity and have shown great preclinical efficacy. In this study, we evaluated a novel multifunctional nanoporphyrin platform loaded with an HSP90 inhibitor 17AAG (NP-AAG) for use as a multi-modality therapy against bladder cancer. NP-AAG was efficiently accumulated and retained at bladder cancer patient-derived xenograft (PDX) over 7 days. PDX tumors could be synergistically eradicated with a single intravenous injection ofNP-AAGfollowed bymultiple light treatments within 7 days. NP-AAGmediated treatment could not only specifically deliver 17AAG and produce heat and reactive oxygen species, but also more effectively inhibit essential bladder cancer essential signaling molecules like Akt, Src, and Erk, as well as HIF-1 alpha induced by photo-therapy. This multifunctional nanoplatform has high clinical relevance and could dramatically improve management for bladder cancers with minimal toxicity. (c) 2018 Elsevier Inc. All rights reserved.
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