文献类型： 外文期刊
作者： Ouyang, Qian-Qian 1 ; Hu, Zhang 1 ; Lin, Zhen-Peng 2 ; Quan, Wei-Yan 1 ; Deng, Yi-Feng 2 ; Li, Si-Dong 1 ; Li, Pu-Wang 4 ;
作者机构： 1.Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China
2.Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524001, Peoples R China
3.Guangdong Ocean Univ, Sch Ocean & Meteorol, Zhanjiang 524088, Peoples R China
4.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
5.Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China
关键词： Chitosan; Marine peptides; Burns healing
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）
ISSN： 0141-8130
年卷期： 2018 年 112 卷
页码：
收录情况： SCI
摘要： The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing. (C) 2018 Elsevier B.V. All rights reserved.
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