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Chitosan-based Nano-biocomposites and their Applications in Medicine and Pharmaceutics

文献类型： 外文期刊

作者： Yang, Ziming 1 ; Li, Puwang 2 ; McDonagh, Andrew 3 ; Li, Sidong 4 ; Lv, Mingzhe 2 ; Li, Yongzhen 2 ; Yu, Ziyang 5 ; Feng, 1 ;

作者机构： 1.Beijing Inst Technol, Mech & Engn Dept, Zhongguancun South St 5, Beijing 100081, Peoples R China

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

3.Univ Technol Sydney, Dept Chem & Biomol Engn, Sydney, NSW 2007, Australia

4.Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China

5.Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

关键词： Chitosan; nano-biocomposites; medicine; pharmaceutics; application; preparation

期刊名称：CURRENT ORGANIC CHEMISTRY （ 影响因子：2.18； 五年影响因子：2.173 ）

ISSN： 1385-2728

年卷期： 2018 年 22 卷 7 期

页码：

收录情况： SCI

摘要： Background: Chitosan-based nano-biocomposite has received more and more attentions in the past few years because of the outstanding merits that chitosan is a natural polymer with biodegradable and biocompatible. Objective: The purpose of the present study is to summarize the different preparation methods of chitosan-based nano-biocomposites, such as electrostatic interaction method, preparation of chitosan-based nano-biocomposites from modified chitosan using self assembly technique, chemical crosslinking approach, metal ions coordination and metal nanoparticles compound methods. In addition, the applications of chitosan-based nanobiocomposites in wound dressing, drug delivery, tissue engineering and biosensors are also discussed. Results: The results show that chitosan-based nano-biocomposites based on nanoparticles or nanohydrogel that can deliver drugs directly to cancer cells at a sustained and controlled rate may provide better efficacy and lower toxicity for the treatment of cancer. Furthermore, chitosan-based nano-biocomposites can enhance the properties of unmodified chitosan and improve the amphipathy, physical and mechanical properties of chitosan and produce new biological functions. Conclusion: It is believed that the rapid development of nano-science and technology must brought broad application prospects for the chitosan-based nano-biocomposites.

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