文献类型： 外文期刊
作者： Pu, Yutian 1 ; Li, Shuhui 1 ; Xiong, Haitao 1 ; Zhang, Xiaofeng 3 ; Wang, Yizhen 1 ; Du, Huahua 1 ;
作者机构： 1.Zhejiang Univ, Coll Anim Sci, Key Lab Anim Feed & Nutr Zhejiang Prov,Minist Agr, Key Lab Anim Nutr & Feed Sci Eastern China, Hangzhou 310058, Zhejiang, Peoples R China
2.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
关键词： iron; neonatal; immunity; intestine; cytokine
期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）
ISSN： 2072-6643
年卷期： 2018 年 10 卷 6 期
页码：
收录情况： SCI
摘要： Early nutrition is key to promoting gut growth and education of the immune system. Although iron deficiency anemia has long been recognized as a serious iron disorder, the effects of iron supplementation on gut development are less clear. Therefore, using suckling piglets as the model for iron deficiency, we assessed the impacts of iron supplementation on hematological status, gut development, and immunity improvement. Piglets were parenterally supplied with iron dextran (FeDex, 60 mg Fe/kg) by intramuscular administration on the third day after birth and slaughtered at the age of two days, five days, 10 days, and 20 days. It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN). FeDex supplementation increased villus length and crypt depth, attenuated the pathological status of the duodenum, and was beneficial to intestinal mucosa. FeDex also influenced the intestinal immune development by stimulating the cytokines' production of the intestine and enhancing the phagocytotic capacity of monocytes. Overall, the present study suggested that iron supplementation helped promote the development of the intestine by improving its morphology, which maintains its mucosal integrity and enhances the expression of immuno-associated factors.
- 相关文献
作者其他论文 更多>>
-
Bioconversion of soybean meal into gut microbiota-targeting polysaccharides via fermentation by Bacillus subtilis
作者：Wang, Cheng;Fu, Lele;Wang, Cheng;Zhang, Yu;Wei, Siyu;Wang, Yizhen;Jin, Mingliang;Zhang, Yu
关键词：Gut microbiota; Polysaccharides; Solid-state fermentation; Soybean meal; Transcriptome
-
Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting M1 polarization
作者：Tang, Xueyou;Zhao, Jing;Liang, Li;Zhang, Kang;Du, Huahua;Li, Yunqin;Zhang, Xiaofeng;Yu, Hong;Du, Huahua;Du, Huahua
关键词：Hemin; HO-1; inflammatory response; iron metabolism; macrophage polarization; macrophages
-
Maternal Folic Acid Supplementation Improves the Intestinal Health of Offspring Porcine by Promoting the Proliferation and Differentiation of Intestinal Stem Cells
作者：Zhang, Yuhui;Chen, Jianjun;Jiang, Shouchuan;Han, Yu;Du, Huahua;Zhang, Xiaofeng
关键词：folic acid; folate; maternal nutrition; proliferation; differentiation; intestinal stem cells
-
Effect of a new tungsten trioxide-based bactericide on the environment of piggeries and piglet health
作者：Chen, Qiangqiang;Cai, Jianfeng;Xiao, Lixia;Zhang, Wei;Ni, Yifan;Zhang, Jinzhi;Hua, Weidong;Zhang, Xiaofeng;Li, Kui
关键词：Weaned piglets; Photocatalytic products; Tungsten trioxide; Microorganisms; Pig house
-
Intraperitoneal supplementation of iron alleviates dextran sodium sulfate-induced colitis by enhancing intestinal barrier function
作者：Liang, Li;Xiong, Qingqing;Tian, Chenying;Miao, Linfeng;Du, Huahua;Kong, Jingxia;Zhang, Xiaofeng
关键词：Iron supplementation; Iron injection; Colitis; Intestinal barrier function
-
Split iron supplementation is beneficial for newborn piglets
作者：Chen, Xiaoyun;Zhao, Jing;Tang, Xueyou;Wang, Fengqin;Du, Huahua;Zhang, Xiaofeng
关键词：Iron deficiency; Iron supplementation; Newborn piglets; Oxidative stress
