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Synergistic potential of fenvalerate and triadimefon on endocrine disruption and oxidative stress during rare minnow embryo development

文献类型： 外文期刊

作者： Wu, Shenggan 1 ; Hu, Gaojie 1 ; Zhao, Xueping 1 ; Wang, Qiang 1 ; Jiang, Jinhua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China

关键词： fenvalerate; endocrine disruption; Gobiocypris rarus; oxidative stress; synergistic effect; triadimefon

期刊名称：ENVIRONMENTAL TOXICOLOGY （ 影响因子：4.119； 五年影响因子：3.404 ）

ISSN： 1520-4081

年卷期： 2018 年 33 卷 7 期

页码：

收录情况： SCI

摘要： Pyrethroids have been reported to interact synergistically when co-exposed with azoles fungicides in different organisms. In the present study, we investigated the mixture toxicity of fenvalerate (FEN) and triadimefon (TDF) toward embryos of Gobiocypris rarus after 96 h exposure. Results demonstrated that TDF enhanced the acute toxicity of FEN. Exposure to binary mixtures of FEN and TDF resulted in synergistic responses of endocrine disruption by inducing the transcripts of several genes including vtg, er, er1, er2, cyp19a, cyp1a, cyp4, cyp11a, gnrh3, gnrhr1a, star, and dmrt1. Furthermore, FEN and TDF mixture increased the VTG level and aromatase activity in rare minnow embryos. FEN and TDF co-exposure also regulated the mRNA of vezf, hsp70, p53, gadd45, induced the synthesis of ROS and activity of GST, suggesting the synergistic potential of oxidative stress induced by FEN and TDF co-exposure. The results indicated that binary mixtures of FEN and TDF could simultaneously induce endocrine disruption and oxidative stress in a synergistic manner during rare minnow embryo development.

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