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Differentiation of isomeric haloanilines by tosylation in combination with electrospray ionization mass spectrometry

文献类型： 外文期刊

作者： Wang, Shanshan 1 ; Cheng, Yuanyuan 1 ; Chen, Mengmeng 2 ; Jiang, Kezhi 2 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Standard Agroprod, Hangzhou, Zhejiang, Peoples R China

2.Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Zhejiang, Peoples R China

关键词： Haloanilines; isomeric differentiation; tosylation; ESI-MS/MS; INC; HPLC

期刊名称：EUROPEAN JOURNAL OF MASS SPECTROMETRY （ 影响因子：1.067； 五年影响因子：0.981 ）

ISSN： 1469-0667

年卷期： 2018 年 24 卷 4 期

页码：

收录情况： SCI

摘要： Differentiation of the isomeric haloanilines still remains a challenging and necessary analytic task due to their identical retention time in chromatography and similar mass spectra. In this work, p-tosylation of haloanilines by reaction of haloanilines with p-toluenesulfonyl chloride resulted in the corresponding N-tosyl haloanilines. Fragmentation of protonated N-tosyl haloanilines in electrospray ionization tandem mass spectrometry (ESI-MS/MS) mainly resulted in tosyl cation, haloaniline radical cation, and halohydroxyaniline radical cation. The MS/MS of the three group isomeric derivatives showed significant difference in abundance distribution of these product ions, respectively. Theoretical calculations showed that the stability of the ion-neutral complex (INC) is a key factor influencing the relative intensity of the product ions. The three group isomeric derivatives were also separated by high performance liquid chromatograph (HPLC) at conventional conditions. p-Tosylation combined tandem MS (or HPLC) technique were carried out to realize the differentiation of isomeric haloanilines.

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