The aqueous extract of Phellinus igniarius (SH) ameliorates dextran sodium sulfate-induced colitis in C57BL/6 mice
文献类型： 外文期刊
作者： Sun, Yuqing 1 ; Zhong, Shi 1 ; Yu, Jiaqi 2 ; Zhu, Jianxun 1 ; Ji, Dongfeng 1 ; Hu, Guiyan 1 ; Wu, Chongming 2 ; Li, Yougu 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Sericultural Res Inst, Hangzhou, Zhejiang, Peoples R China
2.Chinese Acad Med Sci, Pharmacol & Toxicol Res Ctr, Inst Med Plant Dev, Beijing, Peoples R China
3.Peking Union Med Coll, Beijing, Peoples R China
期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）
ISSN： 1932-6203
年卷期： 2018 年 13 卷 10 期
页码：
收录情况： SCI
摘要： Phellinus igniarius, which is called Sanghuang in Chinese, is a fungal herb widely used in Traditional Chinese Medicine to treat stomachache, inflammation and tumors. Recent studies have demonstrated the antitumor, anti-diabetic, anti-inflammatory and immunity-modulating activities of P. igniarius. In the present study, we investigated that ameliorating effect of the aqueous extract of P. igniarius fruiting body (SH) on dextran sodium sulfate (DSS)-induced colitis in C57BL/6 mice. Treatment with SH (250 and 400 mg/kg) for 8 weeks effectively alleviated the pathological indicators of colitis such as bodyweight reduction, disease activity index score, shortening of colon length and abnormal colon histology. The plasma levels of lipopolysaccharide (LPS) and inflammatory factors such as interleukin-6 (IL-6), IL-1 beta and tumor necrosis factor (TNF)-alpha were all significantly reduced. Supplementation of SH (10 mg/L) also inhibited LPS-elicited IL-1 beta production by RAW264.7 macrophages. Real-time PCR and western blot showed that treatment with SH significantly inhibited the phosphorylation of nuclear factor kappa B inhibitor alpha (I kappa B alpha) and decreased the expression of IL-6/IL-1 beta-maturation genes such as apoptosis-associated speck-like protein (ASC3) and caspase-1 in the colon of DSS-induced colitis mice. These results suggest that SH is adequate for the treatment of colitis. Inhibiting the expression and release of inflammatory factors may participate in the colitis-ameliorating effect of SH.
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