您好，欢迎访问福建省农业科学院 机构知识库！
福建省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Comparative pathogenicity of different subtypes of duck hepatitis A virus in Pekin ducklings

文献类型： 外文期刊

作者： Liu, Rongchang 1 ; Shi, Shaohua 1 ; Huang, Yu 1 ; Chen, Zhen 1 ; Chen, Cuiteng 1 ; Cheng, Longfei 2 ; Fu, Guanghua; Ch 1 ;

作者机构： 1.Fujian Acad Agr Sci, Fujian Anim Dis Control Technol Ctr, Fujian Prov Key Lab Avian Dis Control & Prevent, Inst Anim Husb & Vet Med, Fuzhou 350013, Fujian, Peoples R China

2.Fujian Acad Agr Sci, Fujian Anim Dis Control Technol Ctr, Fujian Prov Key Lab Avian Dis Control & Prevent, Inst Anim Husb & Vet Med, Fuzhou 350013, Fujian, Peo

关键词： Duck hepatitis A virus; Virus subtypes; Pathogenicity

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2019 年 228 卷

页码：

收录情况： SCI

摘要： Duck hepatitis A virus (DHAV) is a major pathogen of viral hepatitis in ducks, which is a fatal and contagious disease of young ducklings. Despite the identification of numerous DHAV strains (e.g. DHAV-3, DHAV-2, DHAV-1 and DHAV-1a), the pathogenic differences among the different subtypes have not been evaluated. The objective of this study was to compare the pathogenic properties of three epidemic strains DHAV-3, DHAV-1, and DHAV-1a in mainland China, in a Pekin duckling infection model. We evaluated the pathogenicity of these different subtypes by investigating clinical signs, macroscopic and microscopic lesions, immunohistochemical examination, and viral RNA detection after experimental inoculation of Pekin ducklings with the three different DHAV strains. There was no significant difference in pathogenicity between DHAV-3 and DHAV-1. Pathogenicity of DHAV-1a differed significantly from that of classical duck hepatitis A (DHAV-3 or DHAV-1), in that there were no clinical signs of opisthotonos. More importantly, pancreatic bleeding or yellowing, and spleen swelling and bleeding were the predominant lesions in the DHAV-la group, while liver and spleen lesions were the main signs in classical hepatitis (DHAV-1/3). Our findings indicate that there are differences in the pathogenicity of different subtypes of DHAV in ducklings, which may be useful for understanding the biological characteristics of the different subtypes of DHAV in ducks.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：福建省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台