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Parasitic insect-derived miRNAs modulate host development

文献类型： 外文期刊

作者： Wang, Zhi-zhi 1 ; Ye, Xi-qian 1 ; Shi, Min 1 ; Li, Fei 1 ; Wang, Ze-hua 1 ; Zhou, Yue-nan 1 ; Gu, Qi-juan 1 ; Wu, Xiao-to 1 ;

作者机构： 1.Zhejiang Univ, Inst Insect Sci, Coll Agr & Biotechnol, Hangzhou 310058, Zhejiang, Peoples R China

2.Zhejiang Univ, Key Lab Mol Biol Crop Pathogens & Insect Pests, Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China

3.Zhejiang Univ, State Key Lab Rice Biol, Hangzhou 310058, Zhejiang, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Beijing 100097, Peoples R China

5.BGI Shenzhen, BGI Tech, Shenzhen 518083, Peoples R China

6.Univ Georgia, Dept Entomol, Athens, GA 30602 USA

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Parasitic wasps produce several factors including venom, polydnaviruses (PDVs) and specialized wasp cells named teratocytes that benefit the survival of offspring by altering the physiology of hosts. However, the underlying molecular mechanisms for the alterations remain unclear. Here we find that the teratocytes of Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella, and its associated bracovirus (CvBV) can produce miRNAs and deliver the products into the host via different ways. Certain miRNAs in the parasitized host are mainly produced by teratocytes, while the expression level of miRNAs encoded by CvBV can be 100-fold greater in parasitized hosts than non-parasitized ones. We further show that one teratocyte-produced miRNA (Cve-miR-281-3p) and one CvBV-produced miRNA (Cve-miR-novel22-5p-1) arrest host growth by modulating expression of the host ecdysone receptor (EcR). Altogether, our results show the first evidence of cross-species regulation by miRNAs in animal parasitism and their possible function in the alteration of host physiology during parasitism.

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