Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment
文献类型： 外文期刊
作者： Xue, Xiangdong 1 ; Huang, Yee 1 ; Bo, Ruonan 1 ; Jia, Bei 1 ; Wu, Hao 1 ; Yuan, Ye 1 ; Wang, Zhongling 1 ; Ma, Zhao 1 ; Jing 1 ;
作者机构： 1.Univ Calif Davis, Dept Biochem & Mol Med, UC Davis Comprehens Canc Ctr, Sacramento, CA 95817 USA
2.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet Sci, Hangzhou 310021, Zhejiang, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Radiol, Sch Med, Shanghai 200080, Peoples R China
4.Cent S Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China
5.Wuhan Univ, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China
6.Univ Calif Davis, Div Hematol Oncol, Dept Internal Med, Sacramento, CA 95817 USA
期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）
ISSN： 2041-1723
年卷期： 2018 年 9 卷
页码：
收录情况： SCI
摘要： Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development of a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions. pPhD NPs exhibit ideal size and charge for drug transportation. In tumour microenvironment, pPhD NPs responsively transform to full API nanotheranostics with ultra-small size and higher surface charge, which dramatically facilitate the tumour penetration and cell internalisation. pPhD NPs enable visualisation of biodistribution by near-infrared fluorescence imaging, tumour accumulation and therapeutic effect by magnetic resonance imaging. Moreover, the synergistic photothermal-, photodynamic- and chemo-therapies achieve a 100% complete cure rate on both subcutaneous and orthotopic oral cancer models. This nanoplatform with powerful delivery efficiency and versatile theranostic functions shows enormous potentials to improve cancer treatment.
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