文献类型： 外文期刊

作者： Zheng, Jingui ¹ ; He, Jun ² ; Liao, Sufeng ¹ ; Cheng, Zuxin ¹ ; Lin, Jinke ³ ; Huang, Ke ⁴ ; Li, Xiaocen ² ; Zheng, Kaibi ¹ ;

作者机构： 1.Fujian Agr & Forestry Univ, Agr Prod Qual Inst, Fuzhou, Fujian, Peoples R China

2.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China

3.Fujian Agr & Forestry Univ, Anxi Coll Tea Sci, Fuzhou, Fujian, Peoples R China

4.Hunan Agr Univ, Coll Hort & Landscape, Changsha, Hunan, Peoples R China

5.Fujian Acad Agr Sci, Inst Subtrop Agr, Fuzhou, Fujian, Peoples R China

6.Fujian Agr & Forestry Univ, Minist Educ Genet Breeding & Multiple Utilizat Cr, Key Lab, Fuzhou, Fujian, Peoples R China

关键词： anticancer effects; cancer prevention; combinative natural foods; elite crop variety; hepatocellular carcinoma; N-nitrosodiethylamine

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2019 年 7 卷 1 期

页码：

收录情况： SCI

摘要： The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and evaluated their cancer preventive effects on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. After 20 weeks of dietary intervention, Diet I and Diet II reduced incidence, size, and number of hepatic nodules (p < 0.01) and prevented hepatic tumor formation in NDEA-induced hepatocarcinogenesis rats. Low-grade hepatic dysplasia incidence was 20% for Diet II and 40% for Diet I, and apparent hepatocellular carcinomas (HCC) rates were both 0, while 90% HCC in control diet treatment group (p < 0.01). Diet I and Diet II ameliorated abnormal liver function enzymes, reduced serum alpha fetal protein, tumor-specific growth factor, dickkopf-related protein 1, tumor necrosis factor-alpha and interleukin-6 levels, regulated hepatic phase I and II xenobiotic-metabolizing enzymes, enhanced antioxidant capacity, suppressed NDEA-initiated oxidative DNA damage, and induced apoptosis coupled to down-regulation of proinflammatory, invasion, and angiogenesis markers. Daily intake of combination diet produced from ACEs-rich elite crop varieties can effectively prevent or delay occurrence and development of NDEA-induced hepatocarcinogenesis in rats.