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The Phylogeny and Pathogenesis of Sacbrood Virus (SBV) Infection in European Honey Bees, Apis mellifera

文献类型： 外文期刊

作者： Li, Jianghong 1 ; Wang, Tingyun 2 ; Evans, Jay D. 1 ; Rose, Robyn 3 ; Zhao, Yazhou 1 ; Li, Zhiguo 1 ; Li, Jilian 4 ; Huan 1 ;

作者机构： 1.USDA ARS, Bee Res Lab, BARC East, Bldg 306, Beltsville, MD 20705 USA

2.Fujian Agr & Forestry Univ, Coll Bee Sci, Fuzhou 350002, Fujian, Peoples R China

3.USDA APHIS, Natl Program Manager Honey Bee Hlth, Riverdale, MD 20737 USA

4.Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100081, Peoples R China

5.Consejeria Agr Junta Comunidades Castilla La Manc, Ctr Invest Apicola & Agroambiental, Lab Patol Apicola, IRIAF, Marchamalo 19180, Spain

6.NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

7.Zhejiang Acad Agr Sci, Inst Anim Sci & Vet Med, Hangzhou 310021, Zhejiang, Peoples R China

关键词： honey bee; Sacbrood virus (SBV); genome; genetic variation; phylogeny; cold stress; pathogenicity

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN： 1999-4915

年卷期： 2019 年 11 卷 1 期

页码：

收录情况： SCI

摘要： RNA viruses that contain single-stranded RNA genomes of positive sense make up the largest group of pathogens infecting honey bees. Sacbrood virus (SBV) is one of the most widely distributed honey bee viruses and infects the larvae of honey bees, resulting in failure to pupate and death. Among all of the viruses infecting honey bees, SBV has the greatest number of complete genomes isolated from both European honey bees Apis mellifera and Asian honey bees A. cerana worldwide. To enhance our understanding of the evolution and pathogenicity of SBV, in this study, we present the first report of whole genome sequences of two U.S. strains of SBV. The complete genome sequences of the two U.S. SBV strains were deposited in GenBank under accession numbers: MG545286.1 and MG545287.1. Both SBV strains show the typical genomic features of the Iflaviridae family. The phylogenetic analysis of the single polyprotein coding region of the U.S. strains, and other GenBank SBV submissions revealed that SBV strains split into two distinct lineages, possibly reflecting host affiliation. The phylogenetic analysis based on the 5UTR revealed a monophyletic clade with the deep parts of the tree occupied by SBV strains from both A. cerane and A. mellifera, and the tips of branches of the tree occupied by SBV strains from A. mellifera. The study of the cold stress on the pathogenesis of the SBV infection showed that cold stress could have profound effects on sacbrood disease severity manifested by increased mortality of infected larvae. This result suggests that the high prevalence of sacbrood disease in early spring may be due to the fluctuating temperatures during the season. This study will contribute to a better understanding of the evolution and pathogenesis of SBV infection in honey bees, and have important epidemiological relevance.

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