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Structural characterization and biological fate of lactoferrin-loaded liposomes during simulated infant digestion

文献类型： 外文期刊

作者： Tian, Mengmeng 1 ; Han, Jianzhong 1 ; Ye, Aiqian 1 ; Liu, Weilin 1 ; Xu, Xiankang 1 ; Yao, Yixin 1 ; Li, Kexuan 1 ; Kong, 1 ;

作者机构： 1.Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Dept Food Qual & Safety, Hangzhou, Zhejiang, Peoples R China

2.Massey Univ, Riddet Inst, Palmerston North, New Zealand

3.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang, Peoples R China

4.Minist Agr, Key Lab Trop Crop Prod Proc, Zhanjiang, Peoples R China

关键词： liposome; lactoferrin; infant; in vitro digestion; stability

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：3.638； 五年影响因子：3.802 ）

ISSN： 0022-5142

年卷期： 2019 年 99 卷 6 期

页码：

收录情况： SCI

摘要： BACKGROUND Limited information is concerned on the structure changes of liposomal delivery system under infant conditions. Positively charged lactoferrin (LF)-loaded liposomes, with the entrapment efficiency (EE) of 52.3 +/- 6.3%, were prepared from soybean-derived phospholipids using a thin-layer dispersion method. The structure changes and digestibility of LF-loaded liposomes under infant conditions, including simulated gastric fluid (SGF) and simulated small intestinal fluid (SIF), were characterized in terms of the average particle size, zeta potential, turbidity, fourier transform infrared, transmission electron microscopy, lipolysis and protein hydrolysis. RESULTS This study showed that the functional groups, favorable membrane structure and the EE of liposomes were slightly changed as a function of time when the liposome digested under SGF conditions. However, the intact bilayer structures were damaged and the EE of LF-loaded liposomes decreased to 28.5% after digestion in infant SIF. CONCLUSION These results suggested that liposomal membrane could prevent the gastric degradation and the structure of liposomes was not completely destroyed with a low concentration of pancreatin and bile salts under infant conditions. Present study provided information on the insight into the characteristics of liposomes during infant gastrointestinal digestion, which was useful for the development of microcapsule systems in infant diet. (c) 2018 Society of Chemical Industry

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