Synthesis of gentamicin-grafted-chitosan with improved solubility and antibacterial activity
文献类型： 外文期刊
作者： Yan, Tingting 1 ; Li, Chengpeng 1 ; Ouyang, Qianqian 1 ; Zhang, Dongying 1 ; Zhong, Qingkun 1 ; Li, Puwang 2 ; Li, Sid 1 ;
作者机构： 1.Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China
2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
3.Guangdong Ocean Univ, Sch Ocean & Meteorol, Zhanjiang 524088, Peoples R China
4.Zhengzhou Univ, Sch Nursing, Zhengzhou 450001, Henan, Peoples R China
关键词： Gentamicin; Chitosan; Antibacterial activity; Water solubility
期刊名称：REACTIVE & FUNCTIONAL POLYMERS （ 影响因子：3.975； 五年影响因子：3.914 ）
ISSN： 1381-5148
年卷期： 2019 年 137 卷
页码：
收录情况： SCI
摘要： Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is synthesized for the first time, which is then confirmed by various characteristic methods and the graft ratio for gentamicin is about 22.1%. Particularly, it is the first study, disclosing there are degradation and crosslinking involved simultaneously during CS oxidation. Furthermore, GT-CS shows greatly improved water solubility (10.0w%). Compared to CS, the antibacterial activity of GT-CS is improved significantly, approaching the pure gentamicin. It should be noted that the antimicrobic mechanism may not be the target-specific interactions but the nonspecific interactions with the bacterial membrane as shown by scanning electron microscope. To sum up, GT-CS is a superior antimicrobial with good solubility.
- 相关文献
作者其他论文 更多>>
-
Chitosan-iodine complexes: Preparation, characterization, and antibacterial activity
作者：Zhang, Zhaoyu;Weng, Boya;Hu, Zhang;Si, Zhenyu;Li, Lefan;Cheng, Yu;Yang, Ziming
关键词：Chitosan; Iodine; Antibacterial
-
A triple-signal strategy separated aptasensor for sensitive determination of aflatoxin B1 in peanut based on electrochemical and fluorescent dual-mode
作者：He, Zuyu;Zhang, Mengru;Yang, Ziming;Zhou, Chuang;Wang, Chao;Song, Shuhui;Liu, Yunhao;Chen, Shaohua;Li, Puwang;Zhang, Mengru
关键词：Dual-mode; Triple-signal; Aptasensor; Electrochemical; Fluorescent; Aflatoxin B1
-
Enhanced mechanical properties and antibacterial activities of chitosan films through incorporating zein-gallic acid conjugate stabilized cinnamon essential oil Pickering emulsion
作者：Yang, Linjie;Zhou, Chuang;Liu, Yunhao;He, Zuyu;Zhang, Mengru;Wang, Chao;Yang, Ziming;Li, Puwang;Yang, Linjie;Zhang, Mengru
关键词：Active packaging; Chitosan; Zein; Cinnamon essential oil; Pickering emulsions
-
Mechanical and Degradation Properties of Degradable Cover Materials for Sugarcane Leaves
作者：Jiaoa, Jing;Huang, Xiaohong;Du, Jihua;Zhou, Yirong;Jiaoa, Jing;Song, Shuhui;Li, Puwang;Huang, Xiaohong;Liu, Xinpeng;Song, Shuhui;Zhou, Yirong
关键词：Sugarcane leaves; Degradable; Material properties
-
Photothermal Ti2O3/polyurethane/polyacrylamide foam with high solar-evaporation efficiency
作者：Li, Lefan;Hu, Zhang;Wang, Di;Li, Sidong;Li, Chengpeng;Zhao, Pengfei;Wang, Zhifen;Zhang, Yucang
关键词：Photothermal material; Solar desalination; Dititanium trioxide; Liquified chitin
-
2-Pyridinecarboxaldehyde-Modified Chitosan-Silver Complexes: Optimized Preparation, Characterization, and Antibacterial Activity
作者：Zhang, Zhaoyu;Zhao, Yurong;Hu, Zhang;Si, Zhenyu;Yang, Ziming
关键词：modified chitosan; silver; complex; response surface methodology; antibacterial
-
Potential of Near-Infrared Spectroscopy (NIRS) for Efficient Classification Based on Postharvest Storage Time, Cultivar and Maturity in Coconut Water
作者：Shen, Xiaojun;Li, Xin;Deng, Fuming;Niu, Xiaoqing;Wang, Yuanyuan;Kan, Jintao;Shen, Xiaojun;Wei, Jingyi;Chen, Fusheng;Wang, Tao;Zhang, Weimin;Yun, Yong-Huan;Niu, Xiaoqing;Yun, Yong-Huan
关键词：Cocos nucifera L; liquid endosperm; dwarfs; non-destructive analysis; discrimination
