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Synthesis of gentamicin-grafted-chitosan with improved solubility and antibacterial activity

文献类型： 外文期刊

作者： Yan, Tingting 1 ; Li, Chengpeng 1 ; Ouyang, Qianqian 1 ; Zhang, Dongying 1 ; Zhong, Qingkun 1 ; Li, Puwang 2 ; Li, Sid 1 ;

作者机构： 1.Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

3.Guangdong Ocean Univ, Sch Ocean & Meteorol, Zhanjiang 524088, Peoples R China

4.Zhengzhou Univ, Sch Nursing, Zhengzhou 450001, Henan, Peoples R China

关键词： Gentamicin; Chitosan; Antibacterial activity; Water solubility

期刊名称：REACTIVE & FUNCTIONAL POLYMERS （ 影响因子：3.975； 五年影响因子：3.914 ）

ISSN： 1381-5148

年卷期： 2019 年 137 卷

页码：

收录情况： SCI

摘要： Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is synthesized for the first time, which is then confirmed by various characteristic methods and the graft ratio for gentamicin is about 22.1%. Particularly, it is the first study, disclosing there are degradation and crosslinking involved simultaneously during CS oxidation. Furthermore, GT-CS shows greatly improved water solubility (10.0w%). Compared to CS, the antibacterial activity of GT-CS is improved significantly, approaching the pure gentamicin. It should be noted that the antimicrobic mechanism may not be the target-specific interactions but the nonspecific interactions with the bacterial membrane as shown by scanning electron microscope. To sum up, GT-CS is a superior antimicrobial with good solubility.

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