Effect of dynamic high pressure microfluidization on structure and stability of pluronic F127 modified liposomes
文献类型： 外文期刊
作者： Li, Ziling 1 ; Peng, Shengfeng 1 ; Chen, Xing 1 ; Zhu, Yuqing 1 ; Zou, Liqiang 1 ; Zhou, Wei 3 ; Liu, Wei 1 ; Liu, Chengm 1 ;
作者机构： 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
2.Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang, Jiangxi, Peoples R China
3.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang, Guangdong, Peoples R China
关键词： Pluronic F127; liposomes; dynamic high pressure microfluidization; interaction; stability
期刊名称：JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY （ 影响因子：2.262； 五年影响因子：2.064 ）
ISSN： 0193-2691
年卷期： 2019 年 40 卷 7 期
页码：
收录情况： SCI
摘要： Pluronics modified liposomes have been prepared and shown to enhance stability of liposomes in our previous reports. In this study, we intended to evaluate the effect of dynamic high pressure microfluidization (DHPM) on the structure and stability of pluronic F127 modified liposomes. The results indicated that the particle size of F127 modified liposomes was decreased from 1180.6 nm to 73.5 nm after DHPM treatment. Meanwhile, the morphology was changed from irregularly multilamellar vesicle to spherically unilamellar structure. Structural characteristics were examined by fourier transformed infrared spectrometer, differential scanning calorimetry and X-ray powder diffraction. The subtle difference of structure might be attributed to the incorporation of PPO chains into the bilayer caused by DHPM treatment. Stability studies indicated that DHPM treatment could enhance the storage and membrane stability of F127 modified liposomes. This study may provide more insight to understand the effect of preparation method on the structure and stability of F127 modified liposomes. [GRAPHICS] .
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