文献类型： 外文期刊
作者： Chen, Yang 1 ; Hu, Shuaishuai 1 ; Mu, Lin 1 ; Zhao, Bohao 1 ; Wang, Manman 1 ; Yang, Naisu 1 ; Bao, Guolian 3 ; Zhu, Cige 1 ;
作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, 48 South Univ Ave, Yangzhou 225009, Jiangsu, Peoples R China
2.Yangzhou Univ, Joint Int Res Lab Agr & Agri Prod Safety, Yangzhou 225009, Jiangsu, Peoples R China
3.Zhejiang Acad Agr Sci, Anim Husb & Vet Res Inst, Hangzhou 310000, Zhejiang, Peoples R China
4.Jinling Rabbit Farm, Nanjing 210005, Jiangsu, Peoples R China
关键词： Rex Rabbit; melanocyte; pigmentation; Slc7a11; POU2F1
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）
ISSN： 1422-0067
年卷期： 2019 年 20 卷 10 期
页码：
收录情况： SCI
摘要： Solute carrier family 7 member 11 (Slc7a11) is a cystine/glutamate xCT transporter that controls the production of pheomelanin pigment to change fur and skin color in animals. Previous studies have found that skin expression levels of Slc7a11 varied significantly with fur color in Rex rabbits. However, the molecular regulation mechanism of Slc7a11 in pigmentation is unknown. Here, rabbit melanocytes were first isolated and identified. The distribution and expression pattern of Slc7a11 was confirmed in skin from rabbits with different fur colors. Slc7a11 affected the expression of pigmentation related genes and thus affected melanogenesis. Meanwhile, Slc7a11 decreased melanocyte apoptosis, but inhibition of Slc7a11 enhanced apoptosis. Furthermore, the POU2F1 protein was found to bind to the -713 to -703 bp region of Slc7a11 promoter to inhibit its activity in a dual-luciferase reporter and site-directed mutagenesis assay. This study reveals the function of the Slc7a11 in melanogenesis and provides in-depth analysis of the mechanism of fur pigmentation.
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