Self-assembled amphiphilic chitosan nanomicelles to enhance the solubility of quercetin for efficient delivery
文献类型： 外文期刊
作者： Wang, Hui 1 ; Yang, Ziming 1 ; He, Zuyu 1 ; Zhou, Chuang 1 ; Wang, Chao 1 ; Chen, Yu 4 ; Liu, Xianwu 2 ; Li, Sidong 3 ; Li, 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Key Lab Trop Crop Prod Proc, Minist Agr & Rural Affairs, Zhanjiang 524001, Guangdong, Peoples R China
2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China
3.Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China
4.Beijing Inst Technol, Sch Mat Sci & Engn, 9 Beijing 100081, Peoples R China
关键词： Self-assembled; Amphiphilic chitosan; Quercetin; Nanomicelles; Efficient delivery
期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.268； 五年影响因子：4.957 ）
ISSN： 0927-7765
年卷期： 2019 年 179 卷
页码：
收录情况： SCI
摘要： Quercetin (QCT) has important functions such as antioxidant, anti-inflammatory and anticancer. However, its applications in food and in drug are restricted owing to its poor water solubility. In this work, a novel amphiphilic wall-material chitosan was synthesized via grafting of chitosan with deoxycholic acid (DA) as hydrophobic group and modified N-acetyl-L-cysteine (NAC) as hydrophilic group. Amphiphilic chitosan was self-assembled to load QCT as nanomicelles by a low-cost and inorganic solvent procedure. Both the encapsulation efficiencies (EE) and drug-loading rates (DL) increased when increasing the grafting rate of DA. There was a bursting release of QCT for the QCT-loaded nanomicelles (CS-DA-NAC-QNMs) from 0 to 8 h, and then the release rate decreased gradually. After releasing for 72 h, the final cumulative release percentages were more than 40%. All the QCT-loaded nanomicelles samples showed good hemocompatibility, and their water solubility and biocompatibility increased evidently. What's more, they exhibited an obvious inhibition rate of A549 cells.
- 相关文献
作者其他论文 更多>>
-
Soil aggregate carbon stocks and sequestration efficiency under long-term fertilization across China's croplands
作者：Cheng, Man;Ma, Haiyang;Li, Puwang;Cheng, Man;Shi, Ting;Xu, Minggang;Cheng, Man;Chen, Zhixuan;Wen, Yongli
关键词：Soil aggregation; Carbon distribution; Carbon sequestration efficiency; Long-term fertilization; China' croplands
-
New understanding on iota-carrageenan oxidation by hydrogen peroxide with or without copper sulphate and the properties of oxidized iota-carrageenan
作者：Gu, Qixiang;Zhang, Peng;Zhang, Tong;Deng, Chunmei;Kang, Xinhuang;Li, Chengpeng;Gu, Qixiang;Li, Yongzhen;Li, Puwang;Zhang, Peng;Li, Lihua;Zhang, Tong;Deng, Chunmei;Kang, Xinhuang;Li, Chengpeng;Li, Puwang
关键词：Iota-carrageenan; Oxidation; Antibacterial activity; Copper ion; Cytocompatibility
-
Effect of sex ratio on the life history traits of an important invasive species, Spodoptera frugiperda
作者：Wu, Su-Ran;Wang, Hui;Xiong, Yan;Zhao, Chun-Jie;Ren, Jun-Hua
关键词：
Spodoptera frugiperda ; sex ratio; longevity; fecundity; reproduction -
Reliable and continuous interfacial solar evaporation system with synergetic effects of photothermal and photoluminescence for full-day desalination
作者：Li, Lefan;Li, Tuanzhang;Guo, Jingyuan;Li, Chengpeng;Hu, Zhang;Li, Sidong;Li, Chengyong;Zhao, Pengfei;Li, Chengyong
关键词：
-
Chitosan/acrylic rosin-based superhydrophobic coatings inspired by Pickering emulsion template and lotus leaf surface structure for paper-based food packaging
作者：Lu, Manzhi;Lu, Pan;Liu, Song;Peng, Yingying;Chu, Zhuangzhuang;Hong, Ziyin;Yang, Zhuohong;Hu, Yang;Lu, Manzhi;Hu, Yang;Yang, Ziming
关键词：Coated paper; Chitosan; Lotus leaf surface structure; Pickering emulsion; Water and oil resistance; Food packaging application
-
Preparation of amphiphilic chitosan incorporated with ursolic acid active coating films and its delay of postharvest papaya fruit ripening
作者：Liang, Fengyan;Geng, Jinwen;Cen, Wanqi;Zhao, Miaoyu;Huang, Xunting;Liu, Kaidong;Yang, Ziming;Wei, Changbin;Li, Puwang;Geng, Jinwen;Liang, Fengyan;Liu, Kaidong
关键词：Chitosan; Amphiphilicity; Ursolic acid; Active film; Food preservation
-
Pandan-vanilla rotation mitigates Fusarium wilt disease in vanilla: insights from rhizosphere microbial community shifts
作者：Hong, Shan;Wu, Zhuangsheng;Chen, Yisong;Hong, Shan;Wu, Zhuangsheng;Chen, Yisong;Hong, Shan;Hong, Shan;Hong, Shan;Chen, Yisong;Xing, Yizhang;Zhao, Qingyun;Su, Fan;Zhuang, Huifa;Wang, Hui;Xing, Yizhang;Zhao, Qingyun;Su, Fan;Zhuang, Huifa;Wang, Hui;Xing, Yizhang;Zhao, Qingyun;Su, Fan;Zhuang, Huifa;Wang, Hui;Yang, Jinming
关键词：crop rotation; vanilla; pandan; microbial community; rhizosphere microbiome
