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Tight Junction Proteins in the Weaned Piglet Intestine: Roles and Regulation

文献类型： 外文期刊

作者： Wang, Jing 1 ; Ji, Haifeng 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China

关键词： Tight junction proteins; intestinal barrier impairment; weaned piglet; structure and distribution; influencing factor; nutrition regulation

期刊名称：CURRENT PROTEIN & PEPTIDE SCIENCE （ 影响因子：3.272； 五年影响因子：3.183 ）

ISSN： 1389-2037

年卷期： 2019 年 20 卷 7 期

页码：

收录情况： SCI

摘要： The intestinal epithelial barrier plays a crucial role in the health and growth of weaned piglets. Proper epithelial function mainly depends on tight junctions (TJs), which act as both ion channels and a barrier against noxious molecules. TJs are multiprotein complexes consisting of transmembrane and membrane-associated proteins. Because the intestine in piglets is immature and incomplete, its structure and function are easily impaired by various stresses, infections, and food-related factors. Certain nutrients have been demonstrated to participate in intestinal TJ regulation. Probiotics, amino acids, fibers, oligosaccharide, and certain micronutrients can enhance barrier integrity and counteract infections through elevated TJ protein expression and distribution. In this review, the distribution and classification of intestinal TJs is described, the factors influencing TJs after weaning are summarized, and the regulation of weaning piglet intestinal TJs by nutrients is discussed.

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