文献类型： 外文期刊

作者： Han Hao ¹ ; Guo Zhi-Kai ² ; Zhang Bo ¹ ; Zhang Mei ¹ ; Shi Jing ¹ ; Li Wei ¹ ; Jiao Rui-Hua ¹ ; Tan Ren-Xiang ¹ ; Ge Hui-Min ¹ ;

作者机构： 1.Nanjing Univ, Sch Life Sci, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China

3.Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

关键词： Earwig-associated actinomycete; Phenazine; Biosynthetic pathway; Antimicrobial activity; Acetylcholinesterase inhibitory activity

期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.0； 五年影响因子：2.869 ）

ISSN： 2095-6975

年卷期： 2019 年 17 卷 6 期

页码：

收录情况： SCI

摘要： Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a bio-synthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.