Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students
文献类型： 外文期刊
作者： Fu, Hao 1 ; Chen, Zhixian 2 ; Teng, Weilin 5 ; Du, Zhi 6 ; Zhang, Yan 2 ; Ye, Xiaoli 6 ; Yu, Zaichun 7 ; Zhang, Yinjun 7 ; Pi, Xionge 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Peoples R China
2.Angel Yeast Co Ltd, Natl Key Lab Agr Microbiol, Yichang 443003, Peoples R China
3.Angel Yeast Co Ltd, Hubei Prov Key Lab Yeast Funct, Yichang 443003, Peoples R China
4.Angel Yeast Co Ltd, Yi Chang Engn & Technol Res Ctr Nutr & Hlth Food, Yichang 443003, Peoples R China
5.HangZhou Ctr Dis Control & Prevent, Dept Infect Dis Control & Prevent, Hangzhou 310006, Peoples R China
6.Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Pharm, Hangzhou 310052, Peoples R China
7.Zhejiang Univ Technol, Coll Bioengn, Hangzhou 310014, Peoples R China
8.Zhejiang Acad Agr Sci, Inst Rural Dev, Hangzhou 310021, Peoples R China
关键词： Fructooligosaccharides; Saccharomyces boulardii; in vitro fermentation model; Gut microbiota; Short-chain fatty acids; Gas
期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：6.9； 五年影响因子：7.2 ）
ISSN： 0944-5013
年卷期： 2024 年 285 卷
页码：
收录情况： SCI
摘要： Fructooligosaccharides (FOS) are a common prebiotic widely used in functional foods. Meanwhile, Saccharomyces boulardii is a fungal probiotic frequenly used in the clinical treatment of diarrhea. Compared with single use, the combination of prebiotics and probiotics as symbiotics may be more effective in regulating gut microbiota as recently reported in the literature. The present study aimed to investigate the effects of FOS, S. boulardii and their combination on the structure and metabolism of the gut microbiota in healthy primary and secondary school students using an in vitro fermentation model. The results indicated that S. boulardii alone could not effectively regulate the community structure and metabolism of the microbiota. However, both FOS and the combination of FOS and S. boulardii could effectively regulate the microbiota, significantly inhibiting the growth of Escherichia-Shigella and Bacteroides, and controlling the production of the gases including H2S and NH3. In addition, both FOS and the combination could significantly promote the growth of Bifidobacteria and Lactobacillus, lower environmental pH, and enhance several physiological functions related to synthesis and metabolism. Nevertheless, the combination had more unique benefits as it promoted the growth of Lactobacillus, significantly increased CO2 production and enhanced the functional pathways of carbon metabolism and pyruvic acid metabolism. These findings provide guidance for clinical application and a theoretical basis for the development of synbiotic preparations.
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