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Effects of Toxin-Antitoxin System HicAB on Biofilm Formation by Extraintestinal Pathogenic E. coli

文献类型： 外文期刊

作者： Hou, Bo 1 ; Wang, Chen-Yan 1 ; Li, Shao-Wen 2 ; Zhou, Lun-Jiang 1 ; Che, Yong-Liang 1 ; Chen, Qiu-Yong 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fujian Anim Dis Control Technol Dev Ctr, 104 Xindian Town, Fuzhou 350013, Fujian, Peoples R China

2.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China

期刊名称：CURRENT MICROBIOLOGY （ 影响因子：2.6； 五年影响因子：2.6 ）

ISSN： 0343-8651

年卷期： 2023 年 80 卷 1 期

页码：

收录情况： SCI

摘要： The type II toxin-antitoxin (T-A) HicAB system is abundant in several bacteria and archaea, such as Escherichia coli, Burkholderia Pseudomallei, Yersinia pestis, Pseudomonas aeruginosa, and Streptococcus pneumoniae. This system engages in stress response, virulence, and bacterial persistence. This study showed that the biofilm-forming ability of the hicAB deletion mutant was significantly decreased to moderate ability compared to the extra-intestinal pathogenic Escherichia coli (ExPEC) parent strain and the complemented strain, which are strong biofilm producers. Congo red assay showed that the hicAB mutant maintained the ability to form curli fimbriae. Using RNA-seq and comparative real-time quantitative RT-PCR, we observed the difference in gene expression between the hicAB mutant and the parent strain, which was associated with biofilm formation. Our data indicate that the HicAB type II T-A system has a key role in biofilm formation by ExPEC, which may be associated with outer membrane protein (OMP) gene expression. Collectively, our results indicate that the hicAB type II T-A system is involved in ExPEC biofilm formation.

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