Fabrication, characterization of carboxymethyl konjac glucomannan/ ovalbumin-naringin nanoparticles with improving in vitro bioaccessibility
文献类型： 外文期刊
作者： Tang, Weimin 1 ; Wei, Yanjun 2 ; Lu, Wenjing 2 ; Chen, Di 2 ; Ye, Qin 2 ; Zhang, Cen 2 ; Chen, Yufeng 1 ; Xiao, Chaogeng 2 ;
作者机构： 1.Zhejiang Univ, Coll Opt Sci & Engn, Coll Biosyst Engn & Food Sci, Natl Engn Res Ctr Opt Instruments, Hangzhou 310052, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Food Sci Inst, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China
3.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China
关键词： Flavanone; Bioavailability Enhancement; Nano-delivery system; Water Solubility; Fluorescence Intensity; Encapsulation efficiency (EE)
期刊名称：FOOD CHEMISTRY-X （ 影响因子：6.443； 五年影响因子：6.443 ）
ISSN： 2590-1575
年卷期： 2022 年 16 卷
页码：
收录情况： SCI
摘要： Naringin is potential functional and therapeutic ingredient, has low bioavailability because of poor aqueous solubility. In this study, an ovalbumin (OVA)-carboxymethyl konjac glucomannan (CKGM) nano-delivery system was developed to enhance the bioavailability of naringin. The effects of proportion (OVA: CKGM), pH and naringin concentration were studied on the formation, encapsulation efficiency (EE) and bioaccessibility of OVA/ CKGM-Naringin nanoparticles (OVA/CKGM-Naringin NPs). Its morphology and size were viewed by Scanning Electron Microscope (SEM) and Transmission Electron Microscopy (TEM). The cross-linkage between OVA and CKGM was verified by Fourier Transform Infrared Spectroscopy (FTIR) and Fluorescence Intensity analysis. The size of OVA/CKGM-Naringin NPs were 463.83 +/- 18.50 nm (Polydispersity Index-PDI, 0.42 +/- 0.05). It indicated that 2:1 of OVA: CKGM, pH 3 and 7 mg/mL of naringin concentration were optimized processing parameters of OVA/CKGM-Naringin NPs with EE (97.90 +/- 2.97 %) and remarkably improved bioaccessibility (85.01 +/- 2.52 %). The OVA/CKGM-Naringin NPs was energy efficiently prepared and verified as an ideal carrier of naringin.
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