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Maternal Supplementation with Ornithine Promotes Placental Angiogenesis and Improves Intestinal Development of Suckling Piglets

文献类型： 外文期刊

作者： Yang, Yun 1 ; Hou, Guanyu 1 ; Ji, Fengjie 1 ; Zhou, Hanlin 1 ; Lv, Renlong 1 ; Hu, Chengjun 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crop Genet Resource Res Inst, Haikou 571101, Peoples R China

2.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China

关键词： angiogenesis; placenta; ornithine; intrauterine growth restriction; intestinal development

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2024 年 14 卷 5 期

页码：

收录情况： SCI

摘要： Simple Summary This study aims to investigate the effects of maternal dietary supplementation with ornithine on productive performance and placental angiogenesis of sows. We found that maternal dietary supplementation with 0.15% ornithine increased the average birth weight of piglets and intestinal development of suckling piglets. In addition, Orn facilitated placental angiogenesis by regulating vascular endothelial growth factor-A (VEGF-A). These results indicated that dietary supplementation with 0.15% ornithine is an effective strategy to improve the productive performance of sows.Abstract The blood vessels of the placenta are crucial for fetal growth. Here, lower vessel density and ornithine (Orn) content were observed in placentae for low-birth-weight fetuses versus normal-birth-weight fetuses at day 75 of gestation. Furthermore, the Orn content in placentae decreased from day 75 to 110 of gestation. To investigate the role of Orn in placental angiogenesis, 48 gilts (Bama pig) were allocated into four groups. The gilts in the control group were fed a basal diet (CON group), while those in the experimental groups were fed a basal diet supplemented with 0.05% Orn (0.05% Orn group), 0.10% Orn (0.10% Orn group), and 0.15% Orn (0.15% Orn group), respectively. The results showed that 0.15% Orn and 0.10% Orn groups exhibited increased birth weight of piglets compared with the CON group. Moreover, the 0.15% Orn group was higher than the CON group in the blood vessel densities of placenta. Mechanistically, Orn facilitated placental angiogenesis by regulating vascular endothelial growth factor-A (VEGF-A). Furthermore, maternal supplementation with 0.15% Orn during gestation increased the jejunal and ileal villi height and the concentrations of colonic propionate and butyrate in suckling piglets. Collectively, these results showed that maternal supplementation with Orn promotes placental angiogenesis and improves intestinal development of suckling piglets.

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