文献类型： 外文期刊

作者： Liu, Zijie ¹ ; Ma, Xingbin ¹ ; Li, Shuyu ¹ ; Qiu, Jiajie ¹ ; Liu, Siyu ¹ ; Huang, Zhifeng ¹ ; Lin, Hongling ² ; Abd El-Aty, A. M. ³ ;

作者机构： 1.Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Guangdong, Peoples R China

2.Chinese Acad Trop Agr Sci, Southern Subtrop Crop Res Inst, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China

3.Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt

4.Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Peoples R China

5.Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkiye

关键词： Surface molecularly; imprinted polymer; Novel functional monomer; Diethylene glycol; Sustained release; Salidroside; dimethacrylate

期刊名称：ARABIAN JOURNAL OF CHEMISTRY （ 影响因子：6.0； 五年影响因子：5.9 ）

ISSN： 1878-5352

年卷期： 2023 年 16 卷 10 期

页码：

收录情况： SCI

摘要： This study focuses on creating a green drug release system using a food-grade titanium dioxide (TiO2) material through surface molecular imprinting. Salidroside (SD) was chosen as the template molecule to synthesize molecularly imprinted polymers (SDT-MIP) utilizing TiO2-doped chitosan oligosaccharides as the functional monomer. The SDT-MIPs were characterized using multiple techniques, and their effectiveness was evaluated through an in vitro release study. Additionally, the affinity of SDT-MIPs toward the template molecule was examined using Langmuir and Freundlich adsorption models. The Langmuir model revealed a maximum capacity of 170.41 mg/g and an imprinted factor of 3.4. The study demonstrated that drug release from the SDT-MIPs in simulated gastrointestinal fluid primarily occurred through pure Fick diffusion. The release kinetics exhibited diffusion coefficients ranging from 3.38 x 10-3 cm2/s to 2.78 x 10-2 cm2/s, indicating their biocompatibility and potential application in drug delivery. Furthermore, the SDT-MIP demonstrated no adverse impact on cell viability even at concentrations as high as 1000 lg/mL. The survival rate of cells cultivated in the presence of SDT-MIP solution exceeded 120 & PLUSMN; 12.46%,