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Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1

文献类型： 外文期刊

作者： Yang, Yun 1 ; Liu, Hu 3 ; Zou, Dongbin 1 ; Ji, Fengjie 1 ; Lv, Renlong 1 ; Wu, Hongzhi 1 ; Zhou, Hanlin 1 ; Ren, Ao 4 ; Xu, Tieshan 1 ; Hou, Guanyu 1 ; Hu, Chengjun 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Trop Crop Genet Resource Res Inst, Haikou 571101, Hainan, Peoples R China

2.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Hubei, Peoples R China

3.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang 524013, Guangdong, Peoples R China

4.Changning Jianghe Hitech Agr & Forestry Co Ltd, Hengyang 421500, Hunan, Peoples R China

关键词： Angiogenesis; Meat quality; Polystyrene microplastics; Skeletal muscle; THBS1

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：7.0； 五年影响因子：7.4 ）

ISSN： 0963-9969

年卷期： 2024 年 190 卷

页码：

收录情况： SCI

摘要： Microplastics (MPs) pose a significant threat to livestock health. Yet, the roles of polystyrene MPs (PS-MPs) on meat quality and skeletal muscle development in pigs have not been fully determined. To investigate the effect of PS-MPs on skeletal muscle, piglets were given diets supplementation with 0 mg/kg (CON group), 75 mg/kg (75 mg/kg PS-MPs group), and 150 mg/kg PS-MPs (150 mg/kg PS-MPs group), respectively. The results indicated that the average daily gain (ADG) of piglets in the 150 mg/kg PS-MPs group was significantly lower than that in the CON group. No significant differences were observed in the final body weight and ADG between the CON group and the 75 mg/kg PS-MPs group. Piglets in the 150 mg/kg PS-MPs group exhibited decreased meat redness index and type I muscle fiber density. Metabolomic analysis revealed that the contents of meat flavor compounds carnosine, beta-alanine, palmitic acid, and niacinamide in muscle were lower in the 150 mg/kg PS-MPs group than in the CON group. Additionally, piglets subjected to 150 mg/kg PS-MPs exhibited impaired muscle angiogenesis. Further analysis indicated that PS-MPs exposure up-regulated thrombospondin 1 (THBS1) expression by inhibiting THBS1 mRNA and protein degradation, thereby disrupting skeletal muscle angiogenesis. These findings indicate that PS-MPs exposure adversely affects meat quality and hinders skeletal muscle angiogenesis in pigs, providing deeper insights into the detrimental effects of PS-MPs on meat quality and skeletal muscle development.

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