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Catechin from green tea had the potential to decrease the chlorpyrifos induced oxidative stress in larval zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Zhao, Yun 1 ; Fang, Chanlin 2 ; Jin, Cuiyuan 2 ; Bao, Zhiwei 2 ; Yang, Guiling 3 ; Jin, Yuanxiang 2 ;

作者机构： 1.Hangzhou Acad Agr Sci, Hangzhou 310024, Zhejiang, Peoples R China

2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Catechin; Chlorpyrifos; Oxidative damage; Cell apoptosis; Zebrafish

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.966； 五年影响因子：4.591 ）

ISSN： 0048-3575

年卷期： 2022 年 182 卷

页码：

收录情况： SCI

摘要： Catechin is a biological compound in green tea (Camellia sinesis), which has anti-oxidant, anti-cancer, anti-apoptotic, anti-inflammatory, and attenuated effects in different experimental models. Chlorpyrifos (CPF), a broad-spectrum organophosphate insecticide, has resulted in oxidative stress, mitochondrial dysfunction, and apoptosis in zebrafish. The goal of this study is to assess whether catechin can alleviate CPF-induced oxidative damage and apoptosis in the early developmental stage of zebrafish. According to the results, we observed that 200 mu g/L CPF exposure could induce oxidative stress, ROS production and changing the antioxidant-related enzymes and genes in larval zebrafish. Interestingly, catechin had the potential to reduce the oxidative dam -age and cell apoptosis caused by CPF exposure in larval zebrafish at different endpoints. Especially, catechin could promote the contents of GSH and activity of GST in zebrafish larvae injured by CPF, suggesting that catechin could repair oxidative damage at a certain degree by regulating the activities and gene transcription of some key enzymes related to GSH pathway in zebrafish. In addition, at transcriptional levels, a high concen-tration of catechin exposure reduced the expression genes of Mn-SOD, Cat, gst, and GPX induced by CPF in larval zebrafish. These genes mainly reflected the degree of oxidative damage of zebrafish, which was basically consistent with the enzyme activity. Catechin also could reduce the transcription of p53 and bax, which are tightly related to the apoptosis induced by CPF in zebrafish larvae. The expression of genes was consistent with ROS production, which proved that catechin could alleviate the apoptosis induced by CPF. This study discovered that catechin had some antioxidant effects in aquatic animals to reduce the toxicity caused by pesticides and offered the scientific basis for the utilization and development of catechin.

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