Stereoselective analysis of chiral succinate dehydrogenase inhibitors (SDHIs) in foods of plant origin and animal origin by supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS)
文献类型： 外文期刊
作者： Di, Shanshan 1 ; Zhao, Huiyu 1 ; Liu, Zhenzhen 1 ; Lu, Yuele 3 ; Xu, Hao 1 ; Qi, Peipei 1 ; Wang, Zhiwei 1 ; Wang, Xinquan 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Detect Pesticide Residues & Control Zhejia, Hangzhou 310021, Peoples R China
2.Agr Minist, Key Lab Pesticide Residue Detect, Hangzhou 310021, Peoples R China
3.Hangzhou Jajale Biotech Co Ltd, Hangzhou 310018, Peoples R China
4.Desheng Middle Rd 298, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Chiral SDHIs; Stereoisomer preparation; Absolute configuration; Enantioseparation; Quantitative analysis
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2023 年 411 卷
页码：
收录情况： SCI
摘要： The stereoisomers of chiral SDHIs were prepared using Autoprep HPLC and chiral columns. The method of combining theoretical calculation with experimental determination was used to confirm the absolute configuration of stereoisomer. SFC-MS/MS and four kinds of chiral columns were used to separate the eight chiral SDHIs, and they could be separated simultaneously using OD-3 column in 6.5 min. The integrated QuEChERS strategy was used to analyse the chiral SDHIs in foods of plant and animal origin, and the average recoveries ranged from 71 % to 119 % with RSD <= 18 %, and the LOQ was 1 ng/g. There were 99.2 % and 63.6 % matrix effects were in the range of 0.8-1.2 in foods of plant and animal origin, respectively, showing weak matrix effects. The study provided methods for monitoring chiral SDHIs stereoisomers residues, which were crucial for stereoselective evaluations and improving risk assessments.
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