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Maize lipid droplet-associated protein 2 is recruited by a virus to enhance viral multiplication and infection through regulating cellular fatty acid metabolism

文献类型： 外文期刊

作者： Wang, Siyuan 1 ; Wang, Xinyu 1 ; Li, Siqi 1 ; Sun, Xi 1 ; Xue, Mingshuo 1 ; Di, Dianping 3 ; Zhang, Aihong 3 ; Zhang, Yongjiang 4 ; Xia, Yiji 5 ; Zhou, Tao 1 ; Fan, Zaifeng 1 ;

作者机构： 1.China Agr Univ, Coll Plant Protect, MARA Key Lab Surveillance & Management Plant Quara, Beijing 100193, Peoples R China

2.China Agr Univ, State Key Lab Maize Biobreeding, Beijing 100193, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Plant Protect Inst, Baoding 071000, Peoples R China

4.Chinese Acad Inspect & Quarantine, Beijing 100176, Peoples R China

5.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Peoples R China

6.Chinese Univ Hong Kong, State Key Lab Agrobiotechnol, Hong Kong, Peoples R China

7.China Agr Univ, Sanya Inst, Sanya 572025, Peoples R China

关键词： rice black streaked dwarf virus (RBSDV); C18 polyunsaturated fatty acids; lipid droplets (LDs); LD-associated protein; Zea mays

期刊名称：PLANT JOURNAL （ 影响因子：6.2； 五年影响因子：7.1 ）

ISSN： 0960-7412

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Pathogen infection induces massive reprogramming of host primary metabolism. Lipid and fatty acid (FA) metabolism is generally disrupted by pathogens and co-opted for their proliferation. Lipid droplets (LDs) that play important roles in regulating cellular lipid metabolism are utilized by a variety of pathogens in mammalian cells. However, the function of LDs during pathogenic infection in plants remains unknown. We show here that infection by rice black streaked dwarf virus (RBSDV) affects the lipid metabolism of maize, which causes elevated accumulation of C18 polyunsaturated fatty acids (PUFAs) leading to viral proliferation and symptom development. The overexpression of one of the two novel LD-associated proteins (LDAPs) of maize (ZmLDAP1 and ZmLDAP2) induces LD clustering. The core capsid protein P8 of RBSDV interacts with ZmLDAP2 and prevents its degradation through the ubiquitin-proteasome system mediated by a UBX domain-containing protein, PUX10. In addition, silencing of ZmLDAP2 downregulates the expression of FA desaturase genes in maize, leading to a decrease in C18 PUFAs levels and suppression of RBSDV accumulation. Our findings reveal that plant virus may recruit LDAP to regulate cellular FA metabolism to promote viral multiplication and infection. These results expand the knowledge of LD functions and viral infection mechanisms in plants.

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