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Radioprotective Effects and Mechanisms of One-Year and Seven-Year White Tea Extracts Against 137Cs Radiation-Induced Cell Damage

文献类型： 外文期刊

作者： Xia, Chen 1 ; Cai, Meisheng 2 ; Lu, Yanting 3 ; Wang, Bingkui 3 ; Xu, Linglin 1 ; Wang, Kaixi 1 ; Liu, Zhonghua 1 ;

作者机构： 1.Zhejiang Univ, Coll Agr & Biotechnol, Dept Tea Sci, Hangzhou 310058, Peoples R China

2.Fuding Tea Ind Dev Leading Grp, Ningde 355200, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Crops & Nucl Technol Utilizat, Hangzhou 310021, Peoples R China

关键词： one-year white tea; seven-year white tea; ionizing radiation; cesium; anti-apoptosis; metabolomics

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：5.0 ）

ISSN：

年卷期： 2025 年 30 卷 7 期

页码：

收录情况： SCI

摘要： Ionizing radiation (IR) is widely present in the environment, with 137Cesium (Cs) radiation having particularly severe impacts during nuclear accidents. The objective of our study was to assess the radiation protection or repair effect of one year (WT-1Y) or seven years (WT-7Y) of storage on white teas, as well as to investigate the mechanism of radioprotection. HGC-27 cells exposed to 137Cs gamma-rays (30 Gy) exhibited significant changes in cell structure, apoptosis, ROS, LDH, and their expression of p53 and Caspase-3. The results showed that WT-1Y and WT-7Y acted as antioxidants, showed reduced ROS and LDH levels, and had increased CAT and SOD activities as well as cell survival rate. The WT treatments significantly inhibited apoptosis in both the pre- and post-radiation groups, with WT-1 showing stronger effects in pretreatment by reducing LDH, p53, and Caspase-3 levels and enhancing ROS scavenging and enzyme activities. Post-treatment analysis revealed WT-7 had greater effects on cell viability and SOD activity. Overall, both WT-1 and WT-7 mitigated radiation damage, likely by inhibiting the p53/Caspase-3 apoptosis pathway. A Spearman analysis of the differential metabolites in WT-1Y and WT-7Y with cellular radioprotective indicators revealed that metabolites, such as EGC, procyanidin B4, and phenolic acids (abundant in WT-1Y), quercetin-3-glucosylrutinoside, and caffeine (enriched in WT-7Y) contributed to their distinct effects in the pre- and post-treatment of 137Cs gamma-rays.

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