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Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor

文献类型： 外文期刊

作者： Zhao, Shuang 1 ; Rong, Chengbo 1 ; Gao, Yi 2 ; Wu, Linfeng 1 ; Luo, Xiaoheng 1 ; Song, Shuang 1 ; Liu, Yu 1 ; Wong, Jack 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Inst Agrifood Proc & Nutr, Beijing 100097, Peoples R China

2.Beijing Xicheng Dist Hlth Care Ctr Mothers & Chil, Beijing 100053, Peoples R China

3.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Peoples R China

4.China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China

5.China Agr Univ, Dept Microbiol, Beijing 100193, Peoples R China

6.Huaqiao Univ, Coll Chem Engn, Dept Chem & Pharmaceut Engn, Xiamen 361021, Fujian, Peoples R China

关键词： Ganoderma lucidum spores; Polysaccharide-peptide; Antidepressant; Monoamine neurotransmitters; Corticosterone; Brain-derived neurotrophic factor

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

ISSN： 0175-7598

年卷期： 2021 年 105 卷 23 期

页码：

收录情况： SCI

摘要： A 28-kDa polysaccharide-peptide (PGL) with antidepressant-like activities was isolated from spores of the mushroom Ganoderma lucidum. It was unadsorbed on DEAE-cellulose. Its internal amino acid sequences manifested pronounced similarity with proteins from the mushrooms Lentinula edodes and Agaricus bisporus. The monosaccharides present in 28-kDa PGL comprised predominantly of glucose (over 90%) and much fewer galactose, mannose residues, and other residues. PGL manifested antidepressant-like activities as follows. It enhanced viability and DNA content in corticosterone-injured PC12 cells(a cell line derived from a pheochromocytoma of the rat adrenal medulla with an embryonic origin from the neural crest containing a mixture of neuroblastic cells and eosinophilic cells) and reduced LDH release. A single acute PGL treatment shortened the duration of immobility of mice in both tail suspension and forced swimming tests. PGL treatment enhanced sucrose preference and shortened the duration of immobility in mice exposed to chronic unpredictable mild stress (CUMS). Chronic PGL treatment reversed the decline in mouse brain serotonin and norepinephrine levels but did not affect dopamine levels. PGL decreased serum corticosterone levels and increased BDNF mRNA and protein levels and increased synapsin I and PSD95 levels in the prefrontal cortex. This effect was completely blocked by pretreatment with the BDNF antagonist K252a, indicating that PGL increased synaptic proteins in a BDNF-dependent manner.

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