文献类型： 外文期刊

作者： Chen, Yuting ¹ ; Hao, Zhangsen ² ; Zhao, Han ² ; Duan, Xiaofeng ² ; Jia, Dongsheng ³ ; Li, Kaipeng ² ; Yang, Yuxin ² ; Cui, Hongjuan ⁴ ; Gao, Mingming ⁵ ; Zhao, Ding ² ;

作者机构： 1.Hebei Med Univ, Postdoctoral Res Stn Biol, Shijiazhuang, Hebei, Peoples R China

2.Hebei Med Univ, Sch Pharm, Dept Pharmacognosy, Shijiazhuang 050017, Hebei, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Inst Cash Crops, Shijiazhuang, Hebei, Peoples R China

4.Hebei Inv Biotech Co Ltd, Shijiazhuang, Hebei, Peoples R China

5.Hebei Med Univ, Inst Basic Med, Lab Lipid Metab, Shijiazhuang 050017, Hebei, Peoples R China

6.Fourth Hosp Shijiazhuang, Dept Pharm, Shijiazhuang, Hebei, Peoples R China

关键词： berberine; glucolipid metabolism disorders; intestinal barrier dysfunction; gut microbiota; tryptophan metabolites

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.125； 五年影响因子：4.096 ）

ISSN： 0022-5142

年卷期：

页码：

收录情况： SCI

摘要： BACKGROUND Barberry plants can be considered as useful additives and functional compounds in various industries, especially in the food industry. Berberine (BBR), the most important functional compound in the barberry roots, has recently been used to treat obesity, diabetes, and atherosclerosis. Gut microbiota and the intestinal barrier play an important role in the development of glucolipid metabolism disorders (GLMDs). However, the association of gut microbiota metabolism disorder and the intestinal barrier dysfunction effect of BBR in GLMDs remains elusive. RESULTS The results showed that administration of BBR could increase the number of colonic glands and goblet cell mucus secretion, improve the intestinal barrier function, and reduce the serum glycolipid level in GLMD hamsters. Interestingly, BBR was metabolized into 12 metabolites by gut microbiota, and the main metabolic pathways were oxidation, demethylation, and hydrogenation. In addition, BBR significantly improved the species diversity and uniformity of gut microbiota and promoted the proliferation of beneficial microbiota. Furthermore, the levels of tryptophan metabolites, such as indole, indole-3-acetamide, indole-3-acetaldehyde, indole-3-pyruvic acid, and indole-3-acetic acid were significantly altered by BBR. Both the intestinal tight junction proteins and intestinal immune factors were altered by BBR. CONCLUSION BBR could alleviate intestinal barrier dysfunction of GLMDs by modulating gut microbiota and gut-microbiota-related tryptophan metabolites, which may be one of the pharmacological mechanisms for the treatment of GLMDs. (c) 2022 Society of Chemical Industry.