Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells
文献类型： 外文期刊
作者： Xia, Wen 1 ; Gong, Ersheng 2 ; Lin, Yanyun 3 ; Zheng, Bisheng 1 ; Yang, Wenhan 1 ; Li, Tong 4 ; Zhang, Sheng 1 ; Li, Peng 5 ; Liu, Ruihai 4 ;
作者机构： 1.South China Univ Technol, Overseas Expertise Intro Ctr Discipline Innovat Fo, Ctr 111, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
2.Gannan Med Univ, Sch Publ Hlth & Hlth Management, Ganzhou 341000, Peoples R China
3.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Key Lab Trop Crop Prod Proc,Minist Agr & Rural Aff, Zhanjiang 524001, Peoples R China
4.Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA
5.Guangdong Med Univ, Stem Cell Res & Cellular Therapy Ctr, Affiliated Hosp, Zhanjiang 524001, Peoples R China
关键词： Phenolic extract; Breast cancer; Cell cycle; Apoptosis; Cell proliferation
期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.0； 五年影响因子：8.3 ）
ISSN：
年卷期： 2023 年 12 卷 5 期
页码：
收录情况： SCI
摘要： Polyphenol-rich foods have been shown to be good for cancer prevention as powerful antioxidants. In this study, the mechanisms of wild pink bayberry free phenolic extract (WPBFE) inhibiting the proliferation and inducing apoptotic of MDA-MB-231 breast cancer cells was examined. The main phenolic acids and flavonols in WPBFE were gallic acid ((18.83 & PLUSMN; 0.44) & mu;g/g FW) and myricetin ((1.52 & PLUSMN; 0.05) & mu;g/g FW), respectively. The maximum inhibition rate of WPBFE at non-cytotoxicity dose (below 80 mg/mL) was 81%. Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile, WPBFE induced apoptosis through initiating the mitochondrial death pathway by up-regulating cleaved caspase-3 and enhancing the ratio of Bax/Bcl-2, with the maximum expression levels of 1.29 and 2.03 folds that of control group, respectively. Further study of the upstream protein, we found that WPBFE down-regulated TRAF2, while upregulated p-ASK1, p-p38 and p-p53. Furthermore, WPBFE could down-regulate the expression of p-PI3K and p-Akt. These observations indicated that WPBFE might play an anticancer role through regulating the p38 MAPK together with PI3K/Akt pathway.& COPY; 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- 相关文献
作者其他论文 更多>>
-
Micronization induced gelatinization of tapioca starch and its effects on starch physicochemical and structural properties
作者：Xia, Wen;Xia, Wen;Lin, Yanyun;Wang, Fei;Liu, Rui Hai
关键词：micronization; molecular characteristics; physicochemical properties; tapioca starch; vibrating superfine mill
-
Preparation and physicochemical properties: a new extruded rice using cassava starch and broken rice flour
作者：Xia, Wen;Xia, Wen;Lin, Yanyun;Wang, Fei;Liu, Yunfei;Liu, Rui Hai
关键词：extruded rice; cassava starch; broken rice flour; porous structure; retrogradation
-
Telomere-to-telomere genome of the allotetraploid legume Sesbania cannabina reveals transposon-driven subgenome divergence and mechanisms of alkaline stress tolerance
作者：Luo, Haofei;Wang, Xiaofei;You, Changqing;Wu, Xuedan;Li, Tong;He, Kaixuan;Ye, Qingtong;Zhao, Qinghua;Deng, Xian;Cao, Xiaofeng;Song, Xianwei;Huang, Gai;Luo, Haofei;Wang, Xiaofei;You, Changqing;Wu, Xuedan;Li, Tong;He, Kaixuan;Ye, Qingtong;Zhao, Qinghua;Deng, Xian;Cao, Xiaofeng;Song, Xianwei;Huang, Gai;Wang, Xiaofei;Lv, Zhiyao;He, Kaixuan;Jia, Yajun;You, Changqing;Ye, Qingtong;Cao, Xiaofeng;Pan, Duofeng;Zhang, Dongmei;Shen, Zhongbao;Zhang, Xiaodong;Zhang, Xiaodong;Zhang, Xiaodong;Liu, Guodao
关键词：Sesbania cannabina; alkaline stress; telomere-to-telomere genome; legume; green manure; phosphate transporter; allotetraploid
-
Impact of N,N' -Methylene-bis-Morpholine on the Preservation of Natural Rubber Latex
作者：Zhao, Liguang;Fan, Ruishen;Ding, Li;Song, Yazhong;Li, Jianwei;Wang, Yuekun;Dai, Tuo;Deng, Dayu;Gui, Hongxing;Zhao, Liguang;Ding, Li;Song, Yazhong;Gui, Hongxing;Zhao, Liguang;Li, Jianwei;Wang, Yuekun;Dai, Tuo;Li, Peng;Deng, Dayu
关键词：
-
Intelligent pH-sensing film based on polyvinyl alcohol/cellulose nanocrystal with purple cabbage anthocyanins for visually monitoring shrimp freshness
作者：He, Yunxia;Lu, Lun;Lin, Yanyun;Li, Ruyi;Yuan, Yuan;Lu, Xuli;Zou, Ying;Zhou, Wei;Li, Jihua;Wang, Zhuo;Wang, Zhuo;Lu, Lun;Zhou, Wei
关键词：Intelligent pH-sensing film; Cellulose nanocrystals; Shrimp freshness
-
Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation
作者：Lian, Fengli;Liang, Hanni;Xia, Wen;Gong, Ersheng;Lin, Yanyun;He, Yunxia;Chen, Jun;Hebelstrup, Kim Henrik;Xia, Wen
关键词：
-
Wild pink bayberry fruit: the effect of in vitro gastrointestinal digestion on phytochemical profiles, and antioxidant and antiproliferative activities
作者：Xia, Wen;Lian, Fengli;Zheng, Bisheng;Lin, Yanyun;Gong, Ersheng;Li, Tong;Liu, Ruihai;Zheng, Bisheng
关键词：
