Comprehensive evaluation of chiral sedaxane with four stereoisomers for risk reduction: Bioactivity, toxicity, and stereoselective dissipation in crop planting systems
文献类型： 外文期刊
作者： Di, Shanshan 1 ; Xie, Yunye 1 ; Cang, Tao 1 ; Liu, Zhenzhen 1 ; Chu, Yanyan 4 ; Zhao, Huiyu 1 ; Qi, Peipei 1 ; Wang, Zhiwei 1 ; Wang, Xinquan 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, key Lab Detect Pesticide Residues & Control Zhejia, Hangzhou 310021, Peoples R China
2.Agr Minist, Key Lab Pesticide Residue Detect, Hangzhou 310021, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Peoples R China
4.Ocean Univ China, Sch Med & Pharm, Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao 266200, Peoples R China
5.Desheng Middle Rd 298, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Sedaxane stereoisomers; Fungicidal activity; Mechanism; Acute toxicity; Crop planting systems; Stereoselective dissipation
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2024 年 434 卷
页码：
收录情况： SCI
摘要： A comprehensive evaluation of chiral pesticide at the stereoisomeric level is an effective strategy to improve efficiency and reduce risk on foods. For chiral sedaxane with four stereoisomers, there were 517-1013 fold differences in bioactivity for three kinds of phytopathogens and 3.73 fold differences in toxicity against model organism (Danio rerio) between the best (trans-1R2S-sedaxane) and worst stereoisomer (cis-1S2S-sedaxane). Trans-1R2S-sedaxane had the strongest affinity with the active site than other stereoisomers, which might contribute to the highest bioactivity. Trans-sedaxane was 28.2-331 fold more effective than cis-sedaxane. The dissipation half-lives of sedaxane stereoisomers ranged from 3.28 to 30.7 d in the test crops and soils. Trans- 1S2R-sedaxane and cis-1S2S-sedaxane were preferentially dissipated in corn plants, while the preferential dissipation of trans-1R2S-sedaxane was found in wheat plants, potato plants and corn soil. The preferential dissipation of trans-sedaxane in corn plants, wheat plants, potato plants and corn soil would be environmentally friendly.
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