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Capsid protein of turnip crinkle virus suppresses antiviral RNA decay by degrading Arabidopsis Dcp1 via ubiquitination pathway

文献类型： 外文期刊

作者： Wu, Kunxin 1 ; Xie, Qiuxian 1 ; Liu, Xueting 1 ; Fu, Yan 1 ; Li, Shuxia 1 ; Yu, Xiaoling 1 ; Li, Wenbin 1 ; Zhao, Pingjuan 1 ; Ren, Yanli 3 ; Ruan, Mengbin 1 ; Zhang, Xiuchun 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Hainan, Peoples R China

2.Yili Normal Univ, Coll Biol Sci & Technol, Yining 835000, Peoples R China

3.Chinese Acad Trop Agr Sci, Sanya Res Inst, Sanya 572025, Peoples R China

关键词： turnip crinkle virus; viral suppressor of RNA decay; antiviral; decapping 1; protein degradation

期刊名称：PLANT JOURNAL （ 影响因子：5.7； 五年影响因子：7.0 ）

ISSN： 0960-7412

年卷期： 2025 年 121 卷 5 期

页码：

收录情况： SCI

摘要： RNA decay is a pervasive process in eukaryotic cells. Viruses utilize the host cell's intracellular machinery to gain access to essential molecules and subcellular structures required for infection during the pathogenesis process. The study demonstrates that turnip crinkle virus (TCV) infection enhances the expression of Arabidopsis Dcp1 (AtDcp1), which negatively regulates the accumulation of TCV RNA, indicating its involvement in antiviral defense. Nevertheless, TCV circumvents the antiviral defense based on RNA decay, as indicated by the capsid protein (CP) of TCV stabilizing the known nonsense-mediated RNA decay-targeted transcripts. In vivo, CP physically interacts with AtDcp1, promoting AtDcp1 degradation via ubiquitination pathway. This is evidenced by the observation that the degradation is inhibited by 26S proteasome inhibitors. Furthermore, CP elevates the polyubiquitination of Dcp1-Flag. These data indicate that CP suppresses RNA decay by interacting with AtDcp1 and mediating its degradation through the 26S proteasome pathway, effectively suppressing antiviral RNA decay. This study uncovers a previously unidentified virulence strategy in the ongoing conflict between plants and TCV.

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