Insertion/deletion (Indel) variant of the goat RORA gene is associated with growth traits
文献类型： 外文期刊
作者： Zhou, Qian 1 ; Hu, Huina 1 ; Yang, Yuta 1 ; Kang, Yuxin 1 ; Lan, Xianyong 1 ; Wu, Xianfeng 2 ; Guo, Zhengang 1 ; Pan, Chuanying 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
2.Fujian Acad Agr Sci, Inst Anim Husb & Vet, Fuzhou 350000, Fujian, Peoples R China
3.Anim Husb & Vet Sci Inst Bijie City, Bijie, Guizhou, Peoples R China
关键词： RAR related orphan receptor A (RORA); goat; clock gene; insertion; deletion; growth traits
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要：
RAR related orphan receptor A (RORA), which encodes the retinoid-acid-related orphan receptor alpha (ROR alpha), is a clock gene found in skeletal muscle. Several studies have shown that ROR alpha plays an important role in bone formation, suggesting that RORA gene may take part in the regulation of growth and development. The purpose of this research is to study the insertion/deletion (indel) variations of the RORA gene and investigate the relationship with the growth traits of Shaanbei white cashmere (SBWC) goats. Herein, the current study identified that the P4-11-bp and P11-28-bp deletion sites are polymorphic among 12 pairs of primers within the RORA gene in the SBWC goats (n = 641). Moreover, the P11-28-bp deletion locus was significantly related to the body height (p = 0.046), height at hip cross (p = 0.012), and body length (p = 0.003). Both of P4-11-bp and P11-28-bp indels showed the moderate genetic diversity (0.25
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