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Biodegradation of sulfametoxydiazine by Alcaligenes aquatillis FA: Performance, degradation pathways, and mechanisms

文献类型： 外文期刊

作者： Du, Yuqian 1 ; Cheng, Qilu 2 ; Qian, Mingrong 3 ; Liu, Yangzhi 2 ; Wang, Feng 2 ; Ma, Junwei 2 ; Zhang, Xin 1 ; Lin, Hui 2 ;

作者机构： 1.Zhejiang A&F Univ, Coll Forest & Biotechnol, Hangzhou 311300, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizers, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

3.Zhejiang Shuren Univ, Interdisciplinary Res Acad, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Hangzhou 310015, Peoples R China

关键词： Sulfonamide antibiotic; Biodegradation; Genomics; Transcriptome; Degradation product

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2023 年 452 卷

页码：

收录情况： SCI

摘要： This study reports the isolation and characterization of a novel bacterial strain Alcaligenes aquatillis FA with the ability to degrade sulfametoxydiazine (SMD), a commonly used sulfonamide antibiotic (SA) in livestock and poultry production. The biodegradation kinetics, pathways, and genomic background of SMD by FA were investigated. The results showed that strain FA had high specificity to degrade SMD, and was unable to effectively degrade its isomer, sulfamonomethoxine. The SMD biodegradation followed a first-order kinetic model with a rate constant of 27.39 mg center dot L-1 center dot day(-1) and a half-life of 5.98 days. The biodegradation pathways and detoxification processes of SMD were proposed based on the identification of its biodegradation byproducts and the biotoxicity assessment using both the ecological structure-activity relationship (ECOSAR) model and biological indicator. The involvement of novel degrading enzymes, such as dimethyllsulfone monooxygenase, 4-carboxymuconolactone decarboxylase, and 1,4-benzoquinone reductase, was inferred in the SMD biodegradation process. The presence of sul2 and dfrA genes in strain FA, which were constitutively expressed in its cells, suggests that multiple mechanisms were employed by the strain to resist SMD. This study provides new insights into the biodegradation of sulfonamide antibiotics (SAs) as it is the first to describe an SMD-degrading bacterium and its genetic information.

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