Butyrate in combination with forskolin alleviates necrotic enteritis, increases feed efficiency, and improves carcass composition of broilers
文献类型： 外文期刊
作者： Yang, Qing 1 ; Chen, Binlong 1 ; Robinson, Kelsy 1 ; Belem, Thiago 1 ; Lyu, Wentao 1 ; Deng, Zhuo 1 ; Ramanathan, Ranjith 1 ; Zhang, Guolong 1 ;
作者机构： 1.Oklahoma State Univ, Dept Anim & Food Sci, Stillwater, OK 74078 USA
2.Xichang Univ, Coll Anim Sci, Xichang, Sichuan, Peoples R China
3.USDA ARS, Poultry Prod & Prod Safety Res Unit, Fayetteville, AR USA
4.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China
5.Texas Scottish Rite Hosp Children, Ctr Excellence Hip Disorders, Dallas, TX USA
关键词： Antibiotic alternatives; Butyrate; Forskolin; Necrotic enteritis; Poultry
期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：6.175； 五年影响因子：6.853 ）
ISSN： 1674-9782
年卷期： 2022 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Background The emergence of antimicrobial resistance has necessitated the development of effective alternatives to antibiotics for livestock and poultry production. This study investigated a possible synergy between butyrate and forskolin (a natural labdane diterpene) in enhancing innate host defense, barrier function, disease resistance, growth performance, and meat quality of broilers. Methods The expressions of representative genes involved in host defense (AvBD9 and AvBD10), barrier function (MUC2, CLDN1, and TJP1), and inflammation (IL-1 beta) were measured in chicken HD11 macrophages in response to butyrate and forskolin in the presence or absence of bacterial lipopolysaccharides (LPS). Intestinal lesions and the Clostridium perfringens titers were also assessed in C. perfringens-challenged chickens fed butyrate and forskolin-containing Coleus forskohlii (CF) extract individually or in combination. Furthermore, growth performance and carcass characteristics were evaluated in broilers supplemented with butyrate and the CF extract for 42 d. Results Butyrate and forskolin synergistically induced the expressions of AvBD9, AvBD10, and MUC2 in chicken HD11 cells (P < 0.05) and the synergy was maintained in the presence of LPS. Butyrate and forskolin also suppressed LPS-induced IL-1 beta gene expression in HD11 cells in a synergistic manner (P < 0.05). The two compounds significantly reduced the intestinal lesions of C. perfringens-challenged chickens when combined (P < 0.05), but not individually. Furthermore, butyrate in combination with forskolin-containing CF extract had no influence on weight gain, but significantly reduced feed intake (P < 0.05) with a strong tendency to improve feed efficiency (P = 0.07) in a 42-d feeding trial. Desirably, the butyrate/forskolin combination significantly decreased abdominal fat deposition (P = 0.01) with no impact on the carcass yield, breast meat color, drip loss, or pH of d-42 broilers. Conclusions Butyrate and forskolin has potential to be developed as novel antibiotic alternatives to improve disease resistance, feed efficiency, and carcass composition of broilers.
- 相关文献
作者其他论文 更多>>
-
Linking growth performance and carcass traits with enterotypes in Muscovy ducks
作者：Fan, Qian;Xu, Yini;Yang, Caimei;Lyu, Wentao;Fan, Qian;Xu, Yini;Xiao, Yingping;Lyu, Wentao;Yang, Hua
关键词：Enterotype; Ileal Microbiota; Muscovy Duck; 16S rRNA Gene Sequencing
-
A Bioinspired Photosensitizer Performs Tumor Thermoresistance Reversion to Optimize the Atraumatic Mild-Hyperthermia Photothermal Therapy for Breast Cancer
作者：Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Lyu, Wentao;Xiao, Yingping;Wang, Wen;Lu, Xiaomei;Huang, Wei;Huang, Wei
关键词：atraumatic breast cancer therapy; bioinspired photosensitizer; mild-hyerthermia photothermal therapy; photodynamic effect; tumor thermoresistance
-
Comprehensive identification and risk assessment of regulated and emerging mycotoxins in infant foods and related raw materials and risk management advice: A case study of an infant food company in China
作者：Ji, Xiaofeng;Xiao, Yingping;Wei, Wang;Lyu, Wentao;Wang, Xiaoli;Yang, Hua;Yang, Weikang;Yang, Hua
关键词：Infant food; Wheat; Cereals; Mycotoxins; Food safety; Risk management
-
Tracking investigation of archaeal composition and methanogenesis function from parental to offspring pigs
作者：Chen, Qu;Lyu, Wentao;Pan, Chenglin;Ma, Lingyan;Sun, Yue;Yang, Hua;Wang, Wen;Xiao, Yingping
关键词：Swine gut archaea; Metagenomics; Methanogenesis function; Longitudinal study
-
The fate of Alternaria toxin tenuazonic acid (TeA) during the processing chain of wheat flour products and risk control strategies for mycotoxins
作者：Ji, Xiaofeng;He, Yeyu;Xiao, Yingping;Lyu, Wentao;Yang, Hua;Liang, Ying
关键词：Mycotoxins; Tenuazonic acid; Wheat grain; Flour; Risk assessment; Food safety
-
A tiered approach of hazard-prioritization and risk-ranking for chemical hazards in food commodities: Application for selected mycotoxins
作者：Ji, Xiaofeng;Xiao, Yingping;Lyu, Wentao;Wang, Wen;Yang, Hua;Zhou, Yun;Shao, Kan;Shao, Kan;Yang, Hua
关键词：Risk ranking; Probabilistic MOE; Food contaminants; Infant foods; A tiered approach; Mycotoxins
-
Anaerobutyricum and Subdoligranulum Are Differentially Enriched in Broilers with DisparateWeight Gains
作者：Liu, Jing;Robinson, Kelsy;Lyu, Wentao;Yang, Qing;Wang, Jing;Zhang, Guolong;Robinson, Kelsy;Lyu, Wentao;Yang, Qing;Wang, Jing;Christensen, Karen D.
关键词：body weight; microbiota; microbiome; 16S rRNA gene sequencing; chickens
