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Is secretoneurin a new hormone?

文献类型： 外文期刊

作者： Trudeau, Vance L. 1 ; Martyniuk, Christopher J. 2 ; Zhao, E. 1 ; Hu, Hongxia 4 ; Volkoff, Helene 5 ; Decatur, Wayne 1 ;

作者机构： 1.Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON, Canada

2.Univ New Brunswick, Dept Biol, St John, NB E2L 4L5, Canada

3.Univ New Brunswick, Canadian Rivers Inst, St John, NB E2L 4L5, Canada

4.Beijing Fisheries Res Inst, Beijing, Peoples R China

5.Mem Univ Newfoundland, Dept Biol, St John, NF, Canada

6.Mem Univ Newfoundland, Dept Biochem, St John, NF, Canada

7.Univ New Hampshire, Ctr Mol & Comparat Endocrinol, Durham, NH 03824 USA

8.Univ Ottawa, Ottawa Hosp Res Inst, Chron Dis Program, Ottawa, ON, Canada

关键词： Autocrine;Luteinizing hormone;Neuroendocrine;Paracrine;Secretion;Secretogranins;Secretoneurin

期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：2.822； 五年影响因子：2.772 ）

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收录情况： SCI

摘要： Numerous small potentially bioactive peptides are derived from the selective processing of the ~600 amino acid secretogranin II (SgII) precursor, but only the 31-42 amino acid segment termed secretoneurin (SN) is well-conserved from sharks to mammals. Both SNa and SNb paralogs have been identified in some teleosts, likely arising as a result of the specific genome duplication event in this lineage. Only one copy of the putative lamprey SgII (188 amino acids) could be identified which gives rise to a divergent agnathan SN that contains the signature YTPQ-X-LA-X 7-EL sequence typical of the central core of all known SN peptides. In rodent models, SN has regulatory effects on neuroinflammation and neurotransmitter release, and possesses therapeutic potential for the induction of angiogenesis. The wide distribution of SN in neuroendocrine neurons and pituitary cells suggests important endocrine roles. The clearest example of the endocrine action of SN is the stimulatory effects on pituitary luteinizing hormone release from goldfish pituitary and mouse LβT2 gonadotroph cells, indicative of an important role in reproduction. Several lines of evidence suggest that the SN receptor is most likely a G-protein coupled protein. Microarray analysis of SN effects on dispersed goldfish pituitary cells in vitro reveals novel SN actions that include effects on genes involved in notch signaling and the guanylate cyclase pathway. Intracerebroventricular injection of SN increases feeding and locomotory behaviors in goldfish. Given that SgII appeared early in vertebrate evolution, SN is an old peptide with emerging implications as a new multifunctional hormone.

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[1]Secretoneurin as a hormone regulator in the pituitary. Zhao, E.,Trudeau, Vance L.,Hu, Hongxia. 2010

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