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Cytotoxicity and inhibition of lipid peroxidation activity of resveratrol/cyclodextrin inclusion complexes

文献类型： 外文期刊

作者： Lu, Zhong 1 ; Chen, Rong 1 ; Fu, Ruiguan 2 ; Xiong, Jinyan 1 ; Hu, Yeli 1 ;

作者机构： 1.Wuhan Inst Technol, Hubei Novel Reactor & Green Chem Technol Key Lab, Minist Educ, Key Lab Green Chem Proc, Wuhan 430073, Peoples R China

2.Chinese Acad Trop Agr Sci, Environm & Plant Protect Inst, Danzhou 571737, Hainan, Peoples R China

关键词： Resveratrol;Cyclodextrin;Inclusion complex;Characterization;Cytotoxicity;Lipid peroxidation

期刊名称：JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY （ 影响因子：1.633； 五年影响因子：1.444 ）

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收录情况： SCI

摘要： Resveratrol (Res) is a plant-based polyphenol compound and is known to inhibit the growth of a variety of cancer cells and protect lipoproteins against oxidative damage. However the poor solubility and labile property may constitute a serious problem for its bioavailability. The problem could be overcome by the formation of inclusion complexes with cyclodextrins (CDs). The aim of this work is to include Res by β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-CD) to form the Res/ β-CD and Res/HP-CD inclusion complexes and evaluate their cytotoxicity on cancer cells and inhibition of lipid peroxidation activity. The complexes are characterized by powder X-ray diffraction, fourier transform infrared spectroscopy and scanning electron microscopy. The cytotoxicity of the two complexes has been evaluated by methylthiazoletetrazolium reduction assay on two cancer cell lines (cervical carcinoma cells HeLa and hepatocellular liver cancer cells Hep3B) and one normal cell line (umbililical vein endothelial cell HUVEC). The results showed that the two complexes exhibit high cytotoxicity on two cancer cells, especially for Hep3B, and show no significant effect on normal cells. The Res/HP-CD complex shows higher cytotoxicity on the two cancer cells than that of the Res/β-CD complex. The inhibition of lipid peroxidation induced by Fe~(2+)/ascorbate of the two inclusion complexes has been determined by thiobarbituric acid assay. The inhibition rate shows a linear increase with the increase of CDs concentration, and the Res/HP-CD complex shows stronger inhibition activity than that of the Res/ β-CD complex. The results of this work indicate a potential for using the Res/CD complexes to inhibit human cancer growth and lipoproteins peroxidation.

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