文献类型： 外文期刊

作者： Wu Hai-bo ¹ ; Guo Chao-tan ² ; Lu Ru-feng ³ ; Xu Li-hua ⁴ ; Wo En-kang ² ; You Jin-biao ² ; Wang Yi-ting ² ; Wang Qiao-ga ¹ ;

作者机构： 1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

2.Zhejiang Acad Med Sci, Inst Bioengn, Hangzhou 310013, Zhejiang, Peoples R China

3.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Hangzhou 310006, Zhejiang, Peoples R China

4.Zhejiang Acad Agr Sci, Anim Husb & Vet Inst, Hangzhou 310021, Zhejiang, Peoples R China

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

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收录情况： SCI

摘要： This study describes the characterization of seven H5N1 avian influenza viruses from domestic ducks in Eastern China in 2011. Phylogenetic analysis showed these viruses were closely related to an H5N1 virus circulating in wild birds in Hong Kong. Some characteristics of these viruses were similar to those of an H5N1 strain that circulated in China and Vietnam (2003-2004). The virulence of three isolates was examined in chickens and mice, and they were found to be highly pathogenic in chickens but showed low pathogenicity in mice. These results suggest that continued H5N1 surveillance in poultry should be used as an early warning system for avian influenza outbreaks.