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Differential Effect of Metal Ions on Antibacterial Activity of Chitosan Against Burkholderia cenocepacia

文献类型: 外文期刊

作者: Li, B. 1 ; Fang, Y. 1 ; Shan, C. L. 1 ; Ibrahim, M. 1 ; Xie, G. L. 1 ; Wang, Y. L. 2 ; Sun, G. C. 3 ;

作者机构: 1.Zhejiang Univ, State Key Lab Rice Biol, Key Lab Mol Biol Crop Pathogens & Insects, Minist Agr,Inst Biotechnol, Hangzhou 310029, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Inst Plant Protect & Microbiol, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Inst Plant Protect & Microb

关键词: Antibacterial activity;Burkholderia cenocepacia;Chitosan;Concentration;Metal ions.

期刊名称:ASIAN JOURNAL OF CHEMISTRY ( 影响因子:0.355; 五年影响因子:0.293 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: In this study, the antibacterial activity of chitosan and chitpsan metal salts against Burkholderia cenocepacia isolated from cystic fibrosis patients was investigated. Results showed that chitosan solution at 0.01, 0.05 and 0.10 mg/mL markedly inhibited the growth of B, cenocepacia Y10 although the antibacterial activity decreased with the increase of chitosan concentration. However, the antibacterial activity of chitosan solution against B. cenocepacia Y20 increased with the increase of chitosan concentration up to 0.05 mg/mL. In addition, the antibacterial activity of chitosan solution against B. cenocepacia strains was decreased by NaCl, CaCl2 and MgCl2. However, both ZnCl2 and FeCl3 significantly enhanced the antibacterial activity of chitosan solution regardless of the tested bacterial strains. Overall, the results indicated that chitosan-Zn or chitosan-Fe complex may be a promising candidate for novel antimicrobial agents in pharmaceutical industry.

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