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Pseudorabies viral replication is inhibited by a novel target of miR-21

文献类型： 外文期刊

作者： Huang, Jing 1 ; Ma, Guojian 3 ; Fu, Liangliang 1 ; Jia, Hao 1 ; Zhu, Mengjin 1 ; Li, Xinyun 1 ; Zhao, Shuhong 1 ;

作者机构： 1.Huazhong Agr Univ, Key Lab Agr Anim Gener Breeding & Reprod, Minist Educ, Wuhan 430070, Hubei, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet, Hangzhou 310021, Zhejiang, Peoples R China

3.Chinese Acad Agr Sci, Inst Anim Sci, Key Lab Farm Anim Genet Resources & Utilizat, Minist Agr China, Beijing 100193, Peoples R China

关键词： miR-21;Pseudorabies virus;PK-15;CXCL10;Virus replication

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

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收录情况： SCI

摘要： The pseudorabies virus (PRV) is a porcine virus classified as a member of the Alphaherpesvirinae subfamily of Herpesviridae. Recent studies have confirmed that viruses regulate the gene expression in host cells. Commonly affected genes include oxidative-stress response genes, genes involved in the phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/Akt) signaling pathway, and interferon- and interleukin-related genes. However, the post-transcriptional regulation of host genes following PRV infection is hitherto unclear. In this study, we used miRNA microarray approaches to assess miRNA expression in PRV-infected porcine kidney 15 cell line (PK-15), and observed that miR-21 was expressed at high level 12 h after the cells were infected with PRV. Furthermore, we identified chemokine (C-X-C motif) ligand 10 (CXCL10), also named interferon-y inducible protein-10 (IP-W), as a novel target gene of miR-21. IP-10 was down-regulated at 4 h after PRV infection. PRV replication was significantly inhibited by IP-10 overexpression.

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