浙江省农业科学院机构知识库

Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis

收藏
分享
全文链接

文献类型：外文期刊

作者： Zan, Xinyi ² ; Cui, Fengjie ² ; Li, Yunhong ² ; Yang, Yan ¹ ; Wu, Di ¹ ; Sun, Wenjing ² ; Ping, Lifeng ⁴ ;

作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi, Shanghai 201403, Peoples R China

2.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

3.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China

4.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Hericium erinaceus;Polysaccharide-protein;Anti-tumor activity;Cell cycle;Apoptosis

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （影响因子：6.953；五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： HEG-5 is a novel polysaccharide-protein purified from the fermented mycelia of Hericium erinaceus CZ-2. The present study aims to investigate the effects of HEG-5 on proliferation, cell cycle and apoptosis of human gastric cancer cells SGC-7901. Here, we first uncover that HEG-5 significantly inhibited the proliferation and colony formation of SGC-7901 cells by promoting apoptosis and cell cycle arrest at S phase. RT-PCR and Western blot analysis suggested that HEG-5 could decrease the expressions of Bcl2, PI3K and AKT1, while increase the expressions of Caspase-8, Caspase-3, p53, CDK4, Bax and Bad. These findings indicated that the Caspase-8/-3-dependent, p53-dependent mitochondrial-mediated and PI3k/Akt signaling pathways involved in the molecular events of HEG-5 induced apoptosis and cell cycle arrest. Thus, our study provides in vitro evidence that HEG-5 may be taken as a potential candidate for treating gastric cancer. (C) 2015 Elsevier B.V. All rights reserved.

相关文献

[1]Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. Zhang, Zuofa,Lv, Guoying,Pan, Huijuan,Fan, Leifa,Pandey, Ashok,He, Weiqiang.

[2]Production of Mycelial Biomass and Exo-polymer by Hericium erinaceus CZ-2: Optimization of Nutrients Levels using Response Surface Methodology. Cui, Fengjie,Zhang, Zhicai,Dong, Ying,Huang, Daming,Cui, Fengjie,Liu, Zhiqiang,Ping, Liying,Liu, Zhiqiang,Li, Yin,Ping, Lifeng.

[3]Oxidative injury is involved in fipronil-induced G2/M phase arrest and apoptosis in Spodoptera frugiperda (Sf9) cell line. Wang, Xin-quan,Zhang, Hu,Wang, Xiang-yun,Qi, Pei-pei,Xu, Hao,Li, You-gui,Zhong, Shi. 2013

[4]Mitochondria-mediated Apoptosis in Human Lung Cancer A549 Cells by 4-Methylsulfinyl-3-butenyl Isothiocyanate from Radish Seeds. Wang, Nan,Huo, Po,Liu, Cai-Qin,Jin, Jian-Chang,Wang, Wei,Shen, Lian-Qing. 2014

[5]Over-expression of miR-146b and its regulatory role in intestinal epithelial cell viability, proliferation, and apoptosis in piglets. Tao, Xin,Liu, Shujie,Men, Xiaoming,Xu, Ziwei. 2017

[6]Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Jiang, Jinhua. 2015

[7]Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Jiang, Jinhua,Chen, Yanhong,Yu, Ruixian,Zhao, Xueping,Wang, Qiang,Cai, Leiming. 2016

[8]Inhibition of growth and induction of apoptosis in A549 cells by compounds from oxheart cabbage extract. Wang, Wei,Wang, Nan,Liu, Caiqin,Jin, Jianchang,Shao, Bo,Shen, Lianqing.

[9]Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. Zhong, Shi,Li, You-Gui,Ji, Dong-Feng,Lin, Tian-Bao,Lv, Zhi-Qiang.

[10]Embryonic exposure to carbendazim induces the transcription of genes related to apoptosis, immunotoxicity and endocrine disruption in zebrafish (Danio rerio). Jiang, Jinhua,Wu, Shenggan,Wu, Changxing,An, Xuehua,Cai, Leiming,Zhao, Xueping,Jiang, Jinhua,Wu, Shenggan,Wu, Changxing,An, Xuehua,Cai, Leiming,Zhao, Xueping.

作者其他论文更多>>

Pulsed light reduces postharvest losses of Chinese bayberries by affecting fungal microbiota during cold storage

作者：Wang, Yan;Zheng, Yong;Shang, Jie;Zhou, Aiyun;Cai, Ming;Yang, Kai;Wu, Di;Gao, Haiyan

关键词：Postharvest losses; Pulsed light; Chinese bayberries; Fungal microbiota; Polyphenol oxidase; Phenylalanine ammonia-lyase
Treating carbon-limited wastewater by DWTR and woodchip augmented floating constructed wetlands

作者：Shen, Cheng;Wang, Jie;Shen, Cheng;Liu, Ranbin;Yang, Yan;Zhao, Yaqian;Li, Yan;Liu, Ranbin

关键词：Constructed floating wetland (FCW); Carbon-limited wastewater; Low temperature; Nitrogen removal; Phosphorus fate
Characterization and application of a newly isolated pyrene-degrading bacterium, Pseudomonas monteilii

作者：Ping, Lifeng;Yuan, Xiaoli;Shan, Shengdao;Ping, Lifeng;Zhang, Chunrong;Cui, He;Cui, Juntao

关键词：Microbial degradation;Soil;Pyrene;Pseudomonas monteilii
Biodegradation of pyrene and benzo[a]pyrene in the liquid matrix and soil by a newly identified Raoultella planticola strain

作者：Ping, Lifeng;Yuan, Xiaoli;Ping, Lifeng;Guo, Qian;Chen, Xiaoyang;Zhang, Chunrong;Zhao, Hua

关键词：Pyrene;Benzo[a]pyrene;Raoultella planticola;Identification;Biodegradation
Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells

作者：Cui, Fengjie;Zan, Xinyi;Li, Yunhong;Sun, Wenjing;Cui, Fengjie;Sun, Wenjing;Yang, Yan;Ping, Lifeng;Ping, Lifeng

关键词：
Urban Land Use Classification Using LiDAR Geometric, Spatial Autocorrelation and Lacunarity Features Combined with Postclassification Processing Method

作者：Ma, Ligang;Ding, Jianli;Ma, Ligang;Ding, Jianli;Ma, Fenglan;Ji, Zheng;Gu, Qin;Wu, Di;Deng, Jingsong

关键词：
Isolation and characterization of pyrene and benzo[a]pyrene-degrading Klebsiella pneumonia PL1 and its potential use in bioremediation

作者：Ping, Lifeng;Zhang, Chunrong;Zhang, Changpeng;Zhu, Yahong;He, Hongmei;Wu, Min;Tang, Tao;Li, Zhen;Zhao, Hua;Ping, Lifeng;Zhang, Chunrong;Zhang, Changpeng;Zhu, Yahong;He, Hongmei;Wu, Min;Tang, Tao;Li, Zhen

关键词：Pyrene;Benzo[a]pyrene;Klebsiella pneumoniae;Characterization;Biodegradation

Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis

作者其他论文 更多>>

Pulsed light reduces postharvest losses of Chinese bayberries by affecting fungal microbiota during cold storage

Treating carbon-limited wastewater by DWTR and woodchip augmented floating constructed wetlands

Characterization and application of a newly isolated pyrene-degrading bacterium, Pseudomonas monteilii

Biodegradation of pyrene and benzo[a]pyrene in the liquid matrix and soil by a newly identified Raoultella planticola strain

Grifola frondosa Glycoprotein GFG-3a Arrests S phase, Alters Proteome, and Induces Apoptosis in Human Gastric Cancer Cells

Urban Land Use Classification Using LiDAR Geometric, Spatial Autocorrelation and Lacunarity Features Combined with Postclassification Processing Method

Isolation and characterization of pyrene and benzo[a]pyrene-degrading Klebsiella pneumonia PL1 and its potential use in bioremediation

意 见 箱

作者其他论文更多>>

意见箱